Organic Anion-Transporting Polypeptides at the Blood-Brain and Blood-Cerebrospinal Fluid Barriers

Daniel E. Westholm, Jon N Rumbley, David R. Salo, Timothy P. Rich, Grant W Anderson

Research output: Chapter in Book/Report/Conference proceedingChapter

28 Scopus citations

Abstract

Organic anion-transporting polypeptides (Oatps) are solute carrier family members that exhibit marked evolutionary conservation. Mammalian Oatps exhibit wide tissue expression with an emphasis on expression in barrier cells. In the brain, Oatps are expressed in the blood-brain barrier endothelial cells and blood-cerebrospinal fluid barrier epithelial cells. This expression profile serves to illustrate a central role for Oatps in transporting endo- and xenobiotics across brain barrier cells. This chapter will detail the expression patterns and substrate specificities of Oatps expressed in the brain, and will place special emphases on the role of Oatps in prostaglandin synthesis and in the transport of conjugated endobiotics.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
EditorsGerald Schatten
Pages135-170
Number of pages36
DOIs
StatePublished - 2007

Publication series

NameCurrent Topics in Developmental Biology
Volume80
ISSN (Print)0070-2153

Bibliographical note

Funding Information:
This work was supported, in part, by grants from NIH R01 DK054060 and the University of Minnesota Graduate School (GWA), NIH T32HL07741 (TPR), Research Corporation CC6681 (JNR), and a Melendy Summer Research Scholarship (DRS). Figures 1, 2, 5, 6, and 7 were created using ScienceSlides 2006 software from Visiscience. The authors would like to thank Amber Seys and Anna Malin for their contributions toward the data gathered in Table I .

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