Abstract
The enantioselective oxa-Michael reaction of alkoxyboronate strategy was demonstrated to provide a new and practical route to enantioriched 1- and 3-substituted isochromans using a chiral bifunctional organocatalyst. Furthermore, this methodology was extended to the enantioselective synthesis of (+)-sonepiprazole, a dopamine receptor antagonist.
Original language | English (US) |
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Pages (from-to) | 7008-7018 |
Number of pages | 11 |
Journal | Journal of Organic Chemistry |
Volume | 80 |
Issue number | 14 |
DOIs | |
State | Published - Jul 17 2015 |
Bibliographical note
Publisher Copyright:© 2015 American Chemical Society.