O2 activation by nonheme iron complexes: A monomeric Fe(III)-Oxo complex derived from O2

C. E. MacBeth, A. P. Golombek, Jr Young, C. Yang, K. Kuczera, M. P. Hendrich, A. S. Borovik

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331 Scopus citations

Abstract

Iron species with terminal oxo ligands are implicated as key intermediates in several synthetic and biochemical catalytic cycles. However, there is a dearth of structural information regarding these types of complexes because their instability has precluded isolation under ambient conditions. The isolation and structural characterization of an iron(III) complex with a terminal oxo ligand, derived directly from dioxygen (O2), is reported. A stable structure resulted from placing the oxoiron unit within a synthetic cavity lined with hydrogen-bonding groups. The cavity creates a microenvironment around the iron center that aids in regulating O2 activation and stabilizing the oxoiron unit. These cavities share properties with the active sites of metalloproteins, where function is correlated strongly with site structure.

Original languageEnglish (US)
Pages (from-to)938-941
Number of pages4
JournalScience
Volume289
Issue number5481
DOIs
StatePublished - Aug 11 2000

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