TY - JOUR
T1 - Otitis Interna Induced by Cryptococcus neoformans var. grubii in a Cat
AU - Paulin, J.
AU - Morshed, M.
AU - Armien, Anibal G
PY - 2013/3/13
Y1 - 2013/3/13
N2 - Cryptococcus neoformans var. grubii was identified at necropsy in a case of bilateral otitis interna in a 7-year-old, female, domestic shorthair cat with a 9-day history of acute onset of vestibular disease. Gross examination, including that of the middle and inner ears, was unremarkable. Histologically, the auricular vestibuli, cochleae, and semicircular canals were bilaterally affected by granulomatous inflammation with extracellular and intrahistiocytic yeasts. The yeasts and associated inflammation obstructed and disrupted perilymphatic and endolymphatic spaces of the inner ears. Disruption of the saccular and utricular maculae, cristae ampularis, and organ of Corti, as well as changes in the endolymphatic and perilymphatic fluids, probably impaired the vestibular and auditory functions of this cat. The route of infection was most likely hematogenous.
AB - Cryptococcus neoformans var. grubii was identified at necropsy in a case of bilateral otitis interna in a 7-year-old, female, domestic shorthair cat with a 9-day history of acute onset of vestibular disease. Gross examination, including that of the middle and inner ears, was unremarkable. Histologically, the auricular vestibuli, cochleae, and semicircular canals were bilaterally affected by granulomatous inflammation with extracellular and intrahistiocytic yeasts. The yeasts and associated inflammation obstructed and disrupted perilymphatic and endolymphatic spaces of the inner ears. Disruption of the saccular and utricular maculae, cristae ampularis, and organ of Corti, as well as changes in the endolymphatic and perilymphatic fluids, probably impaired the vestibular and auditory functions of this cat. The route of infection was most likely hematogenous.
KW - Cryptococcus neoformans var. grubii
KW - cat
KW - cochleitis
KW - labyrinthitis
KW - otitis interna
KW - vestibular disease
UR - http://www.scopus.com/inward/record.url?scp=84874770959&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874770959&partnerID=8YFLogxK
U2 - 10.1177/0300985812451623
DO - 10.1177/0300985812451623
M3 - Article
C2 - 22700851
AN - SCOPUS:84874770959
SN - 0300-9858
VL - 50
SP - 260
EP - 263
JO - Veterinary pathology
JF - Veterinary pathology
IS - 2
ER -