Oxidative stress and impaired insulin secretion in type 2 diabetes

R. Paul Robertson

Research output: Contribution to journalReview articlepeer-review

123 Scopus citations

Abstract

Molecular mechanisms involving oxidative stress have been increasingly implicated in the pathogenesis of type 2 diabetes. These implications have arisen from reports that glucolipotoxicity of the pancreatic islet and non-islet tissues can lead to deterioration of islet function and insulin sensitivity, as well as structural abnormalities in tissues adversely affected by diabetes. Co-incident with these changes are profound alterations in insulin gene expression, which involve greatly diminished levels of two transcription factors, MafA and Pdx-1.

Original languageEnglish (US)
Pages (from-to)615-619
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume6
Issue number6
DOIs
StatePublished - Dec 2006

Bibliographical note

Funding Information:
Supported in part by NIH grant NIDDK RO-1 38325.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

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