Oxidative stress, anti-oxidants and the cross-sectional and longitudinal association with depressive symptoms: Results from the CARDIA study

C. N. Black, B. W.J.H. Penninx, M. Bot, A. O. Odegaard, M. D. Gross, K. A. Matthews, D. R. Jacobs

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Depression may be accompanied by increased oxidative stress and decreased circulating anti-oxidants. This study examines the association between depressive symptoms, F2-isoprostanes and carotenoids in a US community sample. The study includes 3009 participants (mean age 40.3, 54.2% female) from CARDIA (Coronary Artery Risk Development in Young Adults). Cross-sectional analyses were performed on data from the year 15 examination (2000–2001) including subjects whose depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) and had measurements of plasma F2-isoprostanes (gas chromatography/mass spectrometry) or serum carotenoids (high-performance liquid chromatography). Carotenoids zeaxanthin/lutein, β-cryptoxanthin, lycopene, α-carotene, β-carotene were standardized and summed. Longitudinal analyses were conducted using the data from other examinations at 5-year intervals. Cross-lagged analyses investigated whether CES-D predicted F2-isoprostanes or carotenoids at the following exam, and vice versa. Regression analyses were controlled for sociodemographics, health and lifestyle factors. F2-isoprostanes were higher in subjects with depressive symptoms (CES-D ≥ 16) after adjustment for sociodemographics (55.7 vs 52.0 pg ml−1; Cohen’s d = 0.14, P<0.001). There was no difference in F2-isoprostanes after further adjustment for health and lifestyle factors. Carotenoids were lower in those with CES-D scores ≥ 16, even after adjustment for health and lifestyle factors (standardized sum 238.7 vs 244.0, Cohen’s d = − 0.16, P<0.001). Longitudinal analyses confirmed that depression predicts subsequent F2-isoprostane and carotenoid levels. Neither F2-isoprostanes nor carotenoids predicted subsequent depression. In conclusion, depressive symptoms were cross-sectionally and longitudinally associated with increased F2-isoprostanes and decreased carotenoids. The association with F2-isoprostanes can largely be explained by lifestyle factors, but lower carotenoids were independently associated with depressive symptoms.

Original languageEnglish (US)
Article numbere743
JournalTranslational psychiatry
Volume6
Issue number2
DOIs
StatePublished - 2016

Bibliographical note

Funding Information:
The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201300025C and HHSN268201300026C), Northwestern University (HHSN268201300027C), University of Minnesota (HHSN268201300028C), Kaiser Foundation Research Institute (HHSN268201300029C) and Johns Hopkins University School of Medicine (HHSN268200900041C). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI (AG0005). This manuscript has been reviewed by CARDIA for scientific content. The Young Adult Longitudinal Trends in Antioxidants Study (YALTA) is supported by the National Heart, Lung, and Blood Institute, National Institutes of Health (R01 HL 53560). CNB and BWJHP are supported through an NWO-VICI grant (number 91811602).

Publisher Copyright:
© 2016, Nature Publishing Group. All rights reserved.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Fingerprint

Dive into the research topics of 'Oxidative stress, anti-oxidants and the cross-sectional and longitudinal association with depressive symptoms: Results from the CARDIA study'. Together they form a unique fingerprint.

Cite this