p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors

José Correa-Basurto, Iván Vázquez Alcántara, L. Michel Espinoza-Fonseca, José G. Trujillo-Ferrara

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33 Scopus citations


Because Alzheimer's disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. The assayed compounds are low toxic, simple-structured and low cost.

Original languageEnglish (US)
Pages (from-to)732-735
Number of pages4
JournalEuropean Journal of Medicinal Chemistry
Issue number7
StatePublished - Jul 2005

Bibliographical note

Funding Information:
The authors thank CONACYT and CGPI for financial support. L.M.E.F. thanks the Ministry of Education of the Slovak Republic for the fellowship granted during the academic year 2003–2004.

Copyright 2008 Elsevier B.V., All rights reserved.


  • Acetylcholine
  • Acetylcholinesterase
  • Amides
  • Enzymatic inhibitors
  • Imides
  • Molecular docking

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