P-selectin and subclinical and clinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA)

Suzette J. Bielinski, Cecilia Berardi, Paul A. Decker, Phillip S. Kirsch, Nicholas B. Larson, James S. Pankow, Michele Sale, Mariza de Andrade, Hugues Sicotte, Weihong Tang, Naomi Q. Hanson, Christina L. Wassel, Joseph F. Polak, Michael Y. Tsai

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Objective: P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population. Methods: Data from the Multi-Ethnic Study of Atherosclerosis (MESA), including 1628 African, 702 Chinese, 2393 non-Hispanic white, and 1302 Hispanic Americans, were used to investigate the association of plasma P-selectin with CHD risk factors, coronary artery calcium (CAC), intima-media thickness, and CHD. Regression models were used to investigate the association between P-selectin and risk factors, Tobit model for CAC, and Cox regression for CHD events. Results: Mean levels of P-selectin differed by ethnicity and were higher in men (P<0.001). For all ethnic groups, P-selectin was positively associated with measures of adiposity, blood pressure, current smoking, LDL, and triglycerides and inversely with HDL. A significant ethnic interaction was observed for the association of P-selectin and prevalent diabetes; however, P-selectin was positively associated with HbA1c in all groups. Higher P-selectin levels were associated with greater prevalence of CAC. Over 10.1 years of follow-up, there were 335 incident CHD events. There was a positive linear association between P-selectin levels and rate of incident CHD after adjustment for traditional risk factors. However, association was only significant in non-Hispanic white Americans (HR: 1.81, 95% CI 1.07 to 3.07, P=0.027). Conclusion: We observed ethnic heterogeneity in the association of P-selectin and risk of CHD.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalAtherosclerosis
Volume240
Issue number1
DOIs
StatePublished - May 1 2015

Bibliographical note

Funding Information:
This study was funded by MESA. MESA is conducted and supported by the National Heart, Lung, and Blood Institute in collaboration with MESA investigators (Grants and contracts N01 HC-95159 , N01-HC-95160 , N01-HC-95161 , N01-HC-95162 , N01-HC-95163 , N01-HC-95164 , N01-HC-95165 , N01-HC-95166 , N01-HC-95167 , N01-HC-95168 , N01-HC-95169 and RR-024156 ). Funding to support adhesion protein measurements was provided by NHLBI ( R01 HL98077 , for abdominal aortic CT by grant R01 HL088451, and for IMT measurements by grants R01 HL069003 and R01 HL081352).

Publisher Copyright:
© 2015 Elsevier Ireland Ltd.

Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.

Keywords

  • Atherosclerosis
  • Cardiovascular risk factors
  • Coronary artery calcium
  • P-selectin

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