TY - JOUR
T1 - P-wave duration and dispersion in patients with obstructive sleep apnea
AU - Can, Ilknur
AU - Aytemir, Kudret
AU - Demir, Ahmet Uǧur
AU - Deniz, Ali
AU - Ciftci, Orcun
AU - Tokgozoglu, Lale
AU - Oto, Ali
AU - Sahin, Altay
PY - 2009/4/17
Y1 - 2009/4/17
N2 - Aim: P-wave dispersion (Pd) has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. The purpose of this study was to investigate Pd in patients with obstructive sleep apnea (OSA) and to determine its relationship with severity of the disease. Methods: The study population included 67 patients referred to sleep laboratory. The Apnea-Hypopnea Index (AHI) was defined as the number of apneas and hypopneas per hour of sleep. Of the sixty-seven patients, 48 had AHI≥5 and were diagnosed as OSA. Nineteen of the patients had AHI < 5 and were diagnosed as OSA (-) (Group 1), 32 of the patients had AHI between 5-30 (mild and moderate, group 2), 16 of the patients had AHI > 30 (severe, group 3). The P-wave duration was calculated in all leads of the surface electrocardiogram. The difference between the maximum (Pmax) and minimum P (Pmin) wave duration was calculated and was defined as the P-wave dispersion (Pd). Echocardiographic examination was also performed. Results: Pmax was longer in group 3 compared to group 2 and group 1 (p = 0.002, p < 0.001 respectively). Pmax was longer in group 2 compared to group 1 (s < 0.001). Pd was greater in group 3 compared to group 2 and group 1 (p < 0.001 for both comparison). Pd was greater in group 2 compared to group 1 (p < 0.001). Pmin did not differ between the groups. In patients with OSA, Pd was positively correlated with AHI (r = 0.56, p < 0.001), BMI (r = 0.43, p = 0.03), and mitral early diastolic to late diastolic velocity (E/A) ratio (r = 0.37, p = 0.01). Multiple linear regression analysis showed that only AHI was independently associated with Pd (β = 0.39, p = 0.02). Conclusion: Pd was found to be greater in patients with OSA than patients without OSA and to be associated with severity of the disease.
AB - Aim: P-wave dispersion (Pd) has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. The purpose of this study was to investigate Pd in patients with obstructive sleep apnea (OSA) and to determine its relationship with severity of the disease. Methods: The study population included 67 patients referred to sleep laboratory. The Apnea-Hypopnea Index (AHI) was defined as the number of apneas and hypopneas per hour of sleep. Of the sixty-seven patients, 48 had AHI≥5 and were diagnosed as OSA. Nineteen of the patients had AHI < 5 and were diagnosed as OSA (-) (Group 1), 32 of the patients had AHI between 5-30 (mild and moderate, group 2), 16 of the patients had AHI > 30 (severe, group 3). The P-wave duration was calculated in all leads of the surface electrocardiogram. The difference between the maximum (Pmax) and minimum P (Pmin) wave duration was calculated and was defined as the P-wave dispersion (Pd). Echocardiographic examination was also performed. Results: Pmax was longer in group 3 compared to group 2 and group 1 (p = 0.002, p < 0.001 respectively). Pmax was longer in group 2 compared to group 1 (s < 0.001). Pd was greater in group 3 compared to group 2 and group 1 (p < 0.001 for both comparison). Pd was greater in group 2 compared to group 1 (p < 0.001). Pmin did not differ between the groups. In patients with OSA, Pd was positively correlated with AHI (r = 0.56, p < 0.001), BMI (r = 0.43, p = 0.03), and mitral early diastolic to late diastolic velocity (E/A) ratio (r = 0.37, p = 0.01). Multiple linear regression analysis showed that only AHI was independently associated with Pd (β = 0.39, p = 0.02). Conclusion: Pd was found to be greater in patients with OSA than patients without OSA and to be associated with severity of the disease.
KW - Obstructive sleep apnea
KW - P dispersion
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U2 - 10.1016/j.ijcard.2007.11.037
DO - 10.1016/j.ijcard.2007.11.037
M3 - Article
C2 - 18192034
AN - SCOPUS:63149107013
SN - 0167-5273
VL - 133
SP - e85-e89
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 3
ER -