P38 Mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide

Medicine & Life Sciences

• mu Opioid Receptor 84%
• Cycloheximide 79%
• Mitogen-Activated Protein Kinase Kinases 78%
• p38 Mitogen-Activated Protein Kinases 74%
• Phosphatidylinositol 3-Kinases 71%
• Up-Regulation 52%
• Morphine 11%
• Methylation 10%
• Opioid Analgesics 10%
• Histone Deacetylase 2 9%
• Phosphoinositide-3 Kinase Inhibitors 8%
• Protein Synthesis Inhibitors 7%
• SB 203580 7%
• Opioid Peptides 7%
• Dactinomycin 6%
• Messenger RNA 6%
• Mitogen-Activated Protein Kinase 1 6%
• Heterozygote 6%
• Acetylation 6%
• Phosphatidylinositol 3-Kinase 6%
• Histones 5%
• Knockout Mice 5%
• Transcriptional Activation 5%
• Psychological Inhibition 4%
• Transcription Factors 4%
• Medicine 4%
• Pharmacology 4%
• Gene Expression 3%
• Pain 3%
• Animals 3%
• In Vitro Techniques 2%
• Genes 2%
• Therapeutics 0%

Chemical Compounds

• Cycloheximide 100%
• Phosphoinositide 65%
• Morphine 57%
• Histone 51%
• LY294002 44%
• Protein Synthesis Inhibitor 39%
• P42 35%
• Actinomycin D 33%
• Protein 29%
• Analgesic 27%
• Acetylation 24%
• Reduction 10%