Abstract
The synthesis and in vitro evaluation of four novel 3-azidobenzoyl photoaffinity analogues of paclitaxel and docetaxel is detailed. Due to their good to excellent ability to stimulate the assembly of microtubules they have potential as photoaffinity probes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 615-620 |
| Number of pages | 6 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 5 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 16 1995 |
Bibliographical note
Funding Information:Acknowledgments: Financial support from the National Institutes of Health (CA 55141 and CA55160) is acknowledged. Support is also acknowledged from the Scientific Education Partnership of Marion Merrell Dow for a postdoctoral fellowship awarded to l’homas C. Boge. We are grateful for the excellent technical assistanceo f Ms. Jeanne Ellermeier. Paclitaxel was provided to us for these studies by the National Cancer Institute and Hauses Chemical Rematch, Inc.
