Paclitaxel and docetaxel photoaffinity labels

Gunda I. Georg, Thomas C. Boge, Haeil Park, Richard H. Himes

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The synthesis and in vitro evaluation of four novel 3-azidobenzoyl photoaffinity analogues of paclitaxel and docetaxel is detailed. Due to their good to excellent ability to stimulate the assembly of microtubules they have potential as photoaffinity probes.

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number6
DOIs
StatePublished - Mar 16 1995

Bibliographical note

Funding Information:
Acknowledgments: Financial support from the National Institutes of Health (CA 55141 and CA55160) is acknowledged. Support is also acknowledged from the Scientific Education Partnership of Marion Merrell Dow for a postdoctoral fellowship awarded to l’homas C. Boge. We are grateful for the excellent technical assistanceo f Ms. Jeanne Ellermeier. Paclitaxel was provided to us for these studies by the National Cancer Institute and Hauses Chemical Rematch, Inc.

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