The synthesis and in vitro evaluation of four novel 3-azidobenzoyl photoaffinity analogues of paclitaxel and docetaxel is detailed. Due to their good to excellent ability to stimulate the assembly of microtubules they have potential as photoaffinity probes.
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Acknowledgments: Financial support from the National Institutes of Health (CA 55141 and CA55160) is acknowledged. Support is also acknowledged from the Scientific Education Partnership of Marion Merrell Dow for a postdoctoral fellowship awarded to l’homas C. Boge. We are grateful for the excellent technical assistanceo f Ms. Jeanne Ellermeier. Paclitaxel was provided to us for these studies by the National Cancer Institute and Hauses Chemical Rematch, Inc.