Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. Isolated from a marine sediment

David E. Williams; Doralyn S. Dalisay; Brian O. Patrick; Teatulohi Matainaho; Kerry Andrusiak; Raamesh Deshpande; Chad L. Myers; Jeff S. Piotrowski; Charles Boone; Minoru Yoshida; Raymond J. Andersen

doi:10.1021/ol2014494

Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. Isolated from a marine sediment

David E. Williams, Doralyn S. Dalisay, Brian O. Patrick, Teatulohi Matainaho, Kerry Andrusiak, Raamesh Deshpande, Chad L. Myers, Jeff S. Piotrowski, Charles Boone, Minoru Yoshida, Raymond J. Andersen

Computer Science and Engineering

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide.

Original language	English (US)
Pages (from-to)	3936-3939
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	15
DOIs	https://doi.org/10.1021/ol2014494
State	Published - Aug 5 2011

Access

10.1021/ol2014494

OpenUrl availability

Full text

Cite this

Williams, D. E., Dalisay, D. S., Patrick, B. O., Matainaho, T., Andrusiak, K., Deshpande, R., Myers, C. L., Piotrowski, J. S., Boone, C., Yoshida, M., & Andersen, R. J. (2011). Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. Isolated from a marine sediment. Organic Letters, 13(15), 3936-3939. https://doi.org/10.1021/ol2014494

@article{0abcf2396a8c416eba4a7287614c86a8,

title = "Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. Isolated from a marine sediment",

abstract = "Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide.",

author = "Williams, {David E.} and Dalisay, {Doralyn S.} and Patrick, {Brian O.} and Teatulohi Matainaho and Kerry Andrusiak and Raamesh Deshpande and Myers, {Chad L.} and Piotrowski, {Jeff S.} and Charles Boone and Minoru Yoshida and Andersen, {Raymond J.}",

year = "2011",

month = aug,

day = "5",

doi = "10.1021/ol2014494",

language = "English (US)",

volume = "13",

pages = "3936--3939",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "15",

}

TY - JOUR

T1 - Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. Isolated from a marine sediment

AU - Williams, David E.

AU - Dalisay, Doralyn S.

AU - Patrick, Brian O.

AU - Matainaho, Teatulohi

AU - Andrusiak, Kerry

AU - Deshpande, Raamesh

AU - Myers, Chad L.

AU - Piotrowski, Jeff S.

AU - Boone, Charles

AU - Yoshida, Minoru

AU - Andersen, Raymond J.

PY - 2011/8/5

Y1 - 2011/8/5

N2 - Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide.

AB - Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide.

UR - http://www.scopus.com/inward/record.url?scp=79961074120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79961074120&partnerID=8YFLogxK

U2 - 10.1021/ol2014494

DO - 10.1021/ol2014494

M3 - Article

C2 - 21749075

AN - SCOPUS:79961074120

SN - 1523-7060

VL - 13

SP - 3936

EP - 3939

JO - Organic Letters

JF - Organic Letters

IS - 15

ER -

Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. Isolated from a marine sediment

Abstract

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this