Abstract
Paeoniflorin (PF), a natural compound isolated from Paeoniae radix, has been shown to exert antitumor effects in various types of human cancers including glioma. However, the mechanism of action is not well understood. S-phase kinase-associated protein (Skp)2 functions as an oncogene in many cancers. In the present study, we investigated whether Skp2 mediates the anti-glioma activity of PF. We found that PF inhibited glioma cell proliferation, migration and invasion, and induced G2/M arrest and apoptosis. Skp2 expression was downregulated in glioma cells treated with PF. PF-induced antitumor effects in glioma cells were abolished by Skp2 over-expression but were enhanced by RNA interference of Skp2. Moreover, PF treatment inhibited U87 cell-derived tumor growth in a xenograft mouse model. These results demonstrate that PF exerts its antitumor effects in part by inhibiting Skp2 expression in glioma cells and could be a promising therapeutic agent for glioma therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1052-1062 |
| Number of pages | 11 |
| Journal | Oncology Reports |
| Volume | 39 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2018 |
| Externally published | Yes |
Bibliographical note
Funding Information:The present study study was financially supported by the following grants: the Program of Medical Innovation Team and Leading Talent of Jiangsu Province, China (no. LJ201150); the Science and Technology Plan Projects of Jiangsu Province, China (no. BL2012048) and the National Natural Sciences Foundation of China (no. 81572480).
Keywords
- Glioma
- Paeoniflorin
- Skp2
