Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides

Yi Yun Yu; Lei Bi; Gunda I. Georg

doi:10.1021/jo400830t

Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides

Yi Yun Yu, Lei Bi, Gunda I. Georg

Medicinal Chemistry

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Abstract

A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs.

Original language	English (US)
Pages (from-to)	6163-6169
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	78
Issue number	12
DOIs	https://doi.org/10.1021/jo400830t
State	Published - Jun 21 2013

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abstract = "A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs.",

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Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides

Abstract

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