Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides

Yi Yun Yu, Lei Bi, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs.

Original languageEnglish (US)
Pages (from-to)6163-6169
Number of pages7
JournalJournal of Organic Chemistry
Issue number12
StatePublished - Jun 21 2013


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