Abstract
This review presents an overview on the present status of xenogeneic islet cell transplantation. In four sections we present (1) a short introduction on clinical islet transplantation using islets from deceased humans, ending with the rationale for xenogeneic islet transplantation; (2) porcine islet survival and function in diabetic nonhuman primates; (3) features in this animal model that are relevant for clinical development; and (4) limitations and translational value of the model in nonhuman primates.
Original language | English (US) |
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Pages (from-to) | 43-50 |
Number of pages | 8 |
Journal | Drug Discovery Today: Disease Models |
Volume | 23 |
DOIs | |
State | Published - Mar 1 2017 |