Parasagittal zones in the cerebellar cortex differ in excitability, information processing, and synaptic plasticity

Timothy J. Ebner; Xinming Wang; Wangcai Gao; Samuel W. Cramer; Gang Chen

doi:10.1007/s12311-011-0347-1

Parasagittal zones in the cerebellar cortex differ in excitability, information processing, and synaptic plasticity

Timothy J. Ebner, Xinming Wang, Wangcai Gao, Samuel W. Cramer, Gang Chen

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36 Scopus citations

Abstract

At the molecular and circuitry levels, the cerebellum exhibits a striking parasagittal zonation as exemplified by the spatial distribution of molecules expressed on Purkinje cells and the topography of the afferent and efferent projections. The physiology and function of the zonation is less clear. Activitydependent optical imaging has proven a useful tool to examine the physiological properties of the parasagittal zonation in the intact animal. Recent findings show that zebrin IIpositive and zebrin II-negative zones differ markedly in their responses to parallel fiber inputs. These findings suggest that cerebellar cortical excitability, information processing, and synaptic plasticity depend on the intrinsic properties of different parasagittal zones.

Original language	English (US)
Pages (from-to)	418-419
Number of pages	2
Journal	Cerebellum
Volume	11
Issue number	2
DOIs	https://doi.org/10.1007/s12311-011-0347-1
State	Published - Jun 2012

Bibliographical note

Funding Information:
Acknowledgments We wish to thank Lijuan Zhou and Michael McPhee for technical support and Kris Bettin for manuscript preparation. This study was supported in part by NIH grants NS048944, NS18338, and NS062158 and a grant from the Minnesota Medical Foundation.

Keywords

Cerebellar cortex
Parallel fibers
Parasagittal zones
Purkinje cells
Zebrin II

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title = "Parasagittal zones in the cerebellar cortex differ in excitability, information processing, and synaptic plasticity",

abstract = "At the molecular and circuitry levels, the cerebellum exhibits a striking parasagittal zonation as exemplified by the spatial distribution of molecules expressed on Purkinje cells and the topography of the afferent and efferent projections. The physiology and function of the zonation is less clear. Activitydependent optical imaging has proven a useful tool to examine the physiological properties of the parasagittal zonation in the intact animal. Recent findings show that zebrin IIpositive and zebrin II-negative zones differ markedly in their responses to parallel fiber inputs. These findings suggest that cerebellar cortical excitability, information processing, and synaptic plasticity depend on the intrinsic properties of different parasagittal zones.",

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note = "Funding Information: Acknowledgments We wish to thank Lijuan Zhou and Michael McPhee for technical support and Kris Bettin for manuscript preparation. This study was supported in part by NIH grants NS048944, NS18338, and NS062158 and a grant from the Minnesota Medical Foundation.",

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AU - Cramer, Samuel W.

AU - Chen, Gang

N1 - Funding Information: Acknowledgments We wish to thank Lijuan Zhou and Michael McPhee for technical support and Kris Bettin for manuscript preparation. This study was supported in part by NIH grants NS048944, NS18338, and NS062158 and a grant from the Minnesota Medical Foundation.

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N2 - At the molecular and circuitry levels, the cerebellum exhibits a striking parasagittal zonation as exemplified by the spatial distribution of molecules expressed on Purkinje cells and the topography of the afferent and efferent projections. The physiology and function of the zonation is less clear. Activitydependent optical imaging has proven a useful tool to examine the physiological properties of the parasagittal zonation in the intact animal. Recent findings show that zebrin IIpositive and zebrin II-negative zones differ markedly in their responses to parallel fiber inputs. These findings suggest that cerebellar cortical excitability, information processing, and synaptic plasticity depend on the intrinsic properties of different parasagittal zones.

AB - At the molecular and circuitry levels, the cerebellum exhibits a striking parasagittal zonation as exemplified by the spatial distribution of molecules expressed on Purkinje cells and the topography of the afferent and efferent projections. The physiology and function of the zonation is less clear. Activitydependent optical imaging has proven a useful tool to examine the physiological properties of the parasagittal zonation in the intact animal. Recent findings show that zebrin IIpositive and zebrin II-negative zones differ markedly in their responses to parallel fiber inputs. These findings suggest that cerebellar cortical excitability, information processing, and synaptic plasticity depend on the intrinsic properties of different parasagittal zones.

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Parasagittal zones in the cerebellar cortex differ in excitability, information processing, and synaptic plasticity

Abstract

Bibliographical note

Keywords

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