Parathyroid hormone change after cinacalcet initiation and one-year clinical outcome risk: A retrospective cohort study Epidemiology and Health Outcomes

Wendy L St Peter; Akeem A. Yusuf; Thy Do; Kimberly A. Lowe; Jiannong Liu; Kimberly M. Nieman; Brian D. Bradbury; Allan J. Collins

doi:10.1186/s12882-015-0030-8

Parathyroid hormone change after cinacalcet initiation and one-year clinical outcome risk: A retrospective cohort study Epidemiology and Health Outcomes

Wendy L St Peter, Akeem A. Yusuf, Thy Do, Kimberly A. Lowe, Jiannong Liu, Kimberly M. Nieman, Brian D. Bradbury, Allan J. Collins

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Abstract

Background: Cinacalcet reduces parathyroid hormone (PTH) levels in patients receiving hemodialysis, but no non-experimental studies have evaluated the association between changes in PTH levels following cinacalcet initiation and clinical outcomes. We assessed whether short-term change in PTH levels after first cinacalcet prescription could serve as a surrogate marker for improvements in longer-term clinical outcomes. Methods: United States Renal Data System data were linked with data from a large dialysis organization.

Original language	English (US)
Article number	41
Journal	BMC Nephrology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s12882-015-0030-8
State	Published - Mar 31 2015

Bibliographical note

Publisher Copyright:
© 2015 St. Peter et al.licensee BioMed Central.

Keywords

Cinacalcet
Hemodialysis
Parathyroid hormone
Secondary hyperparathyroidism

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abstract = "Background: Cinacalcet reduces parathyroid hormone (PTH) levels in patients receiving hemodialysis, but no non-experimental studies have evaluated the association between changes in PTH levels following cinacalcet initiation and clinical outcomes. We assessed whether short-term change in PTH levels after first cinacalcet prescription could serve as a surrogate marker for improvements in longer-term clinical outcomes. Methods: United States Renal Data System data were linked with data from a large dialysis organization.",

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AU - Do, Thy

AU - Lowe, Kimberly A.

AU - Liu, Jiannong

AU - Nieman, Kimberly M.

AU - Bradbury, Brian D.

AU - Collins, Allan J.

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Y1 - 2015/3/31

N2 - Background: Cinacalcet reduces parathyroid hormone (PTH) levels in patients receiving hemodialysis, but no non-experimental studies have evaluated the association between changes in PTH levels following cinacalcet initiation and clinical outcomes. We assessed whether short-term change in PTH levels after first cinacalcet prescription could serve as a surrogate marker for improvements in longer-term clinical outcomes. Methods: United States Renal Data System data were linked with data from a large dialysis organization.

AB - Background: Cinacalcet reduces parathyroid hormone (PTH) levels in patients receiving hemodialysis, but no non-experimental studies have evaluated the association between changes in PTH levels following cinacalcet initiation and clinical outcomes. We assessed whether short-term change in PTH levels after first cinacalcet prescription could serve as a surrogate marker for improvements in longer-term clinical outcomes. Methods: United States Renal Data System data were linked with data from a large dialysis organization.

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KW - Parathyroid hormone

KW - Secondary hyperparathyroidism

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Parathyroid hormone change after cinacalcet initiation and one-year clinical outcome risk: A retrospective cohort study Epidemiology and Health Outcomes

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