TY - JOUR
T1 - Parental Age and Risk of Infant Leukaemia
T2 - A Pooled Analysis
AU - Marcotte, Erin L.
AU - Druley, Todd E.
AU - Johnson, Kimberly J.
AU - Richardson, Michaela
AU - von Behren, Julie
AU - Mueller, Beth A.
AU - Carozza, Susan
AU - McLaughlin, Colleen
AU - Chow, Eric J.
AU - Reynolds, Peggy
AU - Spector, Logan G.
N1 - Publisher Copyright:
© 2017 John Wiley & Sons Ltd
PY - 2017/11
Y1 - 2017/11
N2 - Background: Infant leukaemia (IL) is extremely rare with fewer than 150 cases occurring each year in the United States. Little is known about its causes. However, recent evidence supports a role of de novo mutations in IL aetiology. Parental age has been associated with several adverse outcomes in offspring, including childhood cancers. Given the role of older parental age in de novo mutations in offspring, we carried out an analysis of parental age and IL. Methods: We evaluated the relationship between parental age and IL in a case–control study using registry data from New York, Minnesota, California, Texas, and Washington. Records from 402 cases [219 acute lymphoblastic leukaemia (ALL), 131 acute myeloid leukaemia (AML), and 52 other] and 45 392 controls born during 1981–2004 were analysed. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression. Estimates were adjusted for infant sex, birth year category, maternal race, state, and mutually adjusted for paternal or maternal age, respectively. Results: Infants with mothers' age ≥40 years had an increased risk of developing AML (OR 4.80, 95% CI 1.80, 12.76). In contrast, paternal age <20 was associated with increased risk of ALL (OR 3.69, 95% CI 1.62, 8.41). Conclusion: This study demonstrates increased risk of infant ALL in relation to young paternal age. Given record linkage, there is little concern with recall or selection bias, although data are lacking on MLL gene status and other potentially important variables. Parent of origin effects, de novo mutations, and/or carcinogenic exposures may be involved in IL aetiology.
AB - Background: Infant leukaemia (IL) is extremely rare with fewer than 150 cases occurring each year in the United States. Little is known about its causes. However, recent evidence supports a role of de novo mutations in IL aetiology. Parental age has been associated with several adverse outcomes in offspring, including childhood cancers. Given the role of older parental age in de novo mutations in offspring, we carried out an analysis of parental age and IL. Methods: We evaluated the relationship between parental age and IL in a case–control study using registry data from New York, Minnesota, California, Texas, and Washington. Records from 402 cases [219 acute lymphoblastic leukaemia (ALL), 131 acute myeloid leukaemia (AML), and 52 other] and 45 392 controls born during 1981–2004 were analysed. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression. Estimates were adjusted for infant sex, birth year category, maternal race, state, and mutually adjusted for paternal or maternal age, respectively. Results: Infants with mothers' age ≥40 years had an increased risk of developing AML (OR 4.80, 95% CI 1.80, 12.76). In contrast, paternal age <20 was associated with increased risk of ALL (OR 3.69, 95% CI 1.62, 8.41). Conclusion: This study demonstrates increased risk of infant ALL in relation to young paternal age. Given record linkage, there is little concern with recall or selection bias, although data are lacking on MLL gene status and other potentially important variables. Parent of origin effects, de novo mutations, and/or carcinogenic exposures may be involved in IL aetiology.
KW - childhood cancer
KW - epidemiology
KW - infant leukaemia
KW - maternal age
KW - paternal age
UR - http://www.scopus.com/inward/record.url?scp=85030148918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030148918&partnerID=8YFLogxK
U2 - 10.1111/ppe.12412
DO - 10.1111/ppe.12412
M3 - Article
C2 - 28940632
AN - SCOPUS:85030148918
SN - 0269-5022
VL - 31
SP - 563
EP - 572
JO - Paediatric and perinatal epidemiology
JF - Paediatric and perinatal epidemiology
IS - 6
ER -