TY - JOUR
T1 - Parental history of premature coronary heart disease mortality and signs of ischemia on the resting electrocardiogram
AU - De Bacquer, Dirk
AU - De Backer, Guy
AU - Kornitzer, Marcel
AU - Blackburn, Henry
N1 - Funding Information:
This study was supported by a research grant from the Belgian National Fund for Scientific Research (Brussels, Belgium) (contract no. 3.9002.79). Clinical Studies
PY - 1999/5
Y1 - 1999/5
N2 - OBJECTIVES: Here we explore the association between a family history of premature coronary heart disease (CHD) death and ischemic electrocardiogram (ECG) findings in the offspring. BACKGROUND: In the general population, signs of ischemia are found on the resting ECG in about 10% of middle-aged men and women. Their independent predictive value for CHD morbidity and mortality has been shown in several studies. METHODS: Our results are based on cross- sectional data from three large epidemiological studies performed in Belgium during the past two decades: the Belgian Heart Disease Prevention Project (n = 8,145), the Belgian Interuniversity Research on Nutrition and Health survey (n = 7,625) and the MONICA project (n = 3,193). A parental history of fatal CHD was considered premature if the father died from CHD before age 60 or the mother before age 70. Ischemic ECG findings were defined according to Minnesota Code criteria I1-3, IV1-3, V1-3 or VII1. RESULTS: Subjects with a parental history of premature CHD death were found to have experienced significantly more frequently symptomatic CHD. After exclusion of symptomatic individuals, no major differences in lifestyle-related risk factors were found between the groups with and without a parental history of premature fatal CHD. After multivariate adjustment for age, smoking, body mass index and sex, the odds ratios (and 95% confidence interval [CI]) for ECG ischemia associated with a positive parental history of premature death were 1.42 (1.10-1.82), 1.47 (1.16-1.88) and 1.37 (0.78-2.41) in the three studies. Additional adjustment for systolic blood pressure, total cholesterol and, if available, lifestyle-related factors did not alter the magnitude of the odds ratios. Overall, in men aged 45 to 64 years, ECG ischemia was significantly more frequent (36% excess) in those with positive parental history. CONCLUSIONS: Subjects in whom one or both parents died prematurely from cardiac-related diseases have signs of ischemia more frequently on their electrocardiogram, and this is independent of other risk factors.
AB - OBJECTIVES: Here we explore the association between a family history of premature coronary heart disease (CHD) death and ischemic electrocardiogram (ECG) findings in the offspring. BACKGROUND: In the general population, signs of ischemia are found on the resting ECG in about 10% of middle-aged men and women. Their independent predictive value for CHD morbidity and mortality has been shown in several studies. METHODS: Our results are based on cross- sectional data from three large epidemiological studies performed in Belgium during the past two decades: the Belgian Heart Disease Prevention Project (n = 8,145), the Belgian Interuniversity Research on Nutrition and Health survey (n = 7,625) and the MONICA project (n = 3,193). A parental history of fatal CHD was considered premature if the father died from CHD before age 60 or the mother before age 70. Ischemic ECG findings were defined according to Minnesota Code criteria I1-3, IV1-3, V1-3 or VII1. RESULTS: Subjects with a parental history of premature CHD death were found to have experienced significantly more frequently symptomatic CHD. After exclusion of symptomatic individuals, no major differences in lifestyle-related risk factors were found between the groups with and without a parental history of premature fatal CHD. After multivariate adjustment for age, smoking, body mass index and sex, the odds ratios (and 95% confidence interval [CI]) for ECG ischemia associated with a positive parental history of premature death were 1.42 (1.10-1.82), 1.47 (1.16-1.88) and 1.37 (0.78-2.41) in the three studies. Additional adjustment for systolic blood pressure, total cholesterol and, if available, lifestyle-related factors did not alter the magnitude of the odds ratios. Overall, in men aged 45 to 64 years, ECG ischemia was significantly more frequent (36% excess) in those with positive parental history. CONCLUSIONS: Subjects in whom one or both parents died prematurely from cardiac-related diseases have signs of ischemia more frequently on their electrocardiogram, and this is independent of other risk factors.
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U2 - 10.1016/S0735-1097(99)00067-4
DO - 10.1016/S0735-1097(99)00067-4
M3 - Article
C2 - 10334413
AN - SCOPUS:0033133614
SN - 0735-1097
VL - 33
SP - 1491
EP - 1498
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 6
ER -
