TY - JOUR
T1 - Parental occupational paint exposure and risk of childhood leukemia in the offspring
T2 - findings from the Childhood Leukemia International Consortium
AU - Bailey, Helen D.
AU - Fritschi, Lin
AU - Metayer, Catherine
AU - Infante-Rivard, Claire
AU - Magnani, Corrado
AU - Petridou, Eleni
AU - Roman, Eve
AU - Spector, Logan G.
AU - Kaatsch, Peter
AU - Clavel, Jacqueline
AU - Milne, Elizabeth
AU - Dockerty, John D.
AU - Glass, Deborah C.
AU - Lightfoot, Tracy
AU - Miligi, Lucia
AU - Rudant, Jérémie
AU - Baka, Margarita
AU - Rondelli, Roberto
AU - Amigou, Alicia
AU - Simpson, Jill
AU - Kang, Alice Y.
AU - Moschovi, Maria
AU - Schüz, Joachim
N1 - Publisher Copyright:
© 2014, Springer International Publishing Switzerland.
PY - 2014/10/11
Y1 - 2014/10/11
N2 - Purpose: It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring.Methods: We obtained individual level data from 13 case–control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression.Results: Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95 % confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95 % CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95 % CI 0.65, 1.41) and 1.31 (95 % CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest.Conclusions: Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.
AB - Purpose: It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring.Methods: We obtained individual level data from 13 case–control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression.Results: Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95 % confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95 % CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95 % CI 0.65, 1.41) and 1.31 (95 % CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest.Conclusions: Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.
KW - Childhood
KW - Leukemia
KW - Meta-analysis
KW - Paint
KW - Parental occupation
KW - Pooled analysis
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U2 - 10.1007/s10552-014-0441-z
DO - 10.1007/s10552-014-0441-z
M3 - Article
C2 - 25088805
AN - SCOPUS:84911002174
SN - 0957-5243
VL - 25
SP - 1351
EP - 1367
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 10
ER -
