TY - JOUR
T1 - Patent ductus arteriosus occlusion in small dogs utilizing a low profile Amplatz® canine duct occluder prototype
AU - Stauthammer, Christopher D
AU - Olson, Janet
AU - Leeder, Damon
AU - Hohnadel, Kristin
AU - Hanson, Melissa
AU - Tobias, Anthony H.
N1 - Funding Information:
The study was funded by St. Jude Medical.
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/9
Y1 - 2015/9
N2 - Objectives: To develop procedural methodology and assess the safety, utility and effectiveness of a low profile Amplatz® canine duct occluder (ACDO) prototype in dogs deemed too small to undergo ductal occlusion with the commercially-available ACDO device. Animals: Twenty-one dogs with left-to-right shunting patent ductus arteriosus (PDA). Dogs were ≥1.5 kg but considered too small to accommodate a 6 Fr catheter or 4 Fr sheath within the femoral artery. Methods: Prospective canine study using a low profile ACDO prototype delivered through a 4 Fr catheter via a femoral arterial approach. Procedural methods, fluoroscopy time, perioperative complications, and residual ductal flow were evaluated, and angiographic ductal morphology and dimensions were tabulated. Results: All 21 dogs underwent successful ductal occlusion using the prototype device, 4 Fr catheter, and right femoral artery approach. No perioperative complications or device embolization occurred. The median minimal ductal diameter was 1.9 mm (range, 0.4–3.4), and the median device size deployed was 4 mm (range, 3–6). Complete ductal occlusion was noted in 17 dogs (81%) on post-deployment angiography. Twenty dogs (95%) had no residual flow on echocardiography performed the following day. In the 17 dogs (81%) that returned for a long-term (≥3months) follow-up evaluation, all had complete ductal occlusion based on echocardiography. Conclusions: The low profile ACDO prototype is a safe and effective method of PDA occlusion in the small dog. The deployment procedure appears of similar technical difficulty to the commercially available ACDO.
AB - Objectives: To develop procedural methodology and assess the safety, utility and effectiveness of a low profile Amplatz® canine duct occluder (ACDO) prototype in dogs deemed too small to undergo ductal occlusion with the commercially-available ACDO device. Animals: Twenty-one dogs with left-to-right shunting patent ductus arteriosus (PDA). Dogs were ≥1.5 kg but considered too small to accommodate a 6 Fr catheter or 4 Fr sheath within the femoral artery. Methods: Prospective canine study using a low profile ACDO prototype delivered through a 4 Fr catheter via a femoral arterial approach. Procedural methods, fluoroscopy time, perioperative complications, and residual ductal flow were evaluated, and angiographic ductal morphology and dimensions were tabulated. Results: All 21 dogs underwent successful ductal occlusion using the prototype device, 4 Fr catheter, and right femoral artery approach. No perioperative complications or device embolization occurred. The median minimal ductal diameter was 1.9 mm (range, 0.4–3.4), and the median device size deployed was 4 mm (range, 3–6). Complete ductal occlusion was noted in 17 dogs (81%) on post-deployment angiography. Twenty dogs (95%) had no residual flow on echocardiography performed the following day. In the 17 dogs (81%) that returned for a long-term (≥3months) follow-up evaluation, all had complete ductal occlusion based on echocardiography. Conclusions: The low profile ACDO prototype is a safe and effective method of PDA occlusion in the small dog. The deployment procedure appears of similar technical difficulty to the commercially available ACDO.
KW - Angiography
KW - Cardiac catheterization
KW - Congenital
KW - Intervention
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U2 - 10.1016/j.jvc.2015.06.002
DO - 10.1016/j.jvc.2015.06.002
M3 - Article
C2 - 26363940
AN - SCOPUS:85027925308
SN - 1760-2734
VL - 17
SP - 203
EP - 209
JO - Journal of Veterinary Cardiology
JF - Journal of Veterinary Cardiology
IS - 3
ER -