TY - JOUR
T1 - Pathogenesis of porcine parvovirus infection
T2 - Pathology and immunofluorescence in the foetus
AU - Joo, H. S.
AU - Donaldson-Wood, C. R.
AU - Johnson, R. H.
AU - Campbell, R. S.F.
N1 - Funding Information:
We wish to thank Messrs L. R. Reilly and P. Verrall pathology. This work was funded by the Australian Committee.
PY - 1977/7
Y1 - 1977/7
N2 - Porcine foetuses of dams experimentally infected with porcine parvovirus (PPV) showed differing histopathological and immunofluorescent characteristics dependent on gestational age. Histopathological changes without immunofluorescence were evident in foetuses which had passed the stage of immunocompetence, whilst less obvious histopathological changes with significant antigen fluorescence were present in foetuses which had not reached immunocompetence. Such fluorescence was evident in the parenchyma of lung, liver and kidney, and in neurons and vascular endothelium of the cerebrum. Histopathological changes consisted of some vasculitis, perivascular infiltrations and meningitis of the brain, interstitial hepatitis, interstitial nephritis and placentitis with calcification.
AB - Porcine foetuses of dams experimentally infected with porcine parvovirus (PPV) showed differing histopathological and immunofluorescent characteristics dependent on gestational age. Histopathological changes without immunofluorescence were evident in foetuses which had passed the stage of immunocompetence, whilst less obvious histopathological changes with significant antigen fluorescence were present in foetuses which had not reached immunocompetence. Such fluorescence was evident in the parenchyma of lung, liver and kidney, and in neurons and vascular endothelium of the cerebrum. Histopathological changes consisted of some vasculitis, perivascular infiltrations and meningitis of the brain, interstitial hepatitis, interstitial nephritis and placentitis with calcification.
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U2 - 10.1016/0021-9975(77)90028-7
DO - 10.1016/0021-9975(77)90028-7
M3 - Article
C2 - 332722
AN - SCOPUS:0017396908
SN - 0021-9975
VL - 87
SP - 383
EP - 391
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
IS - 3
ER -
