TY - JOUR
T1 - Pathologic changes of the peripheral vestibular system secondary to chronic otitis media
AU - Da Costa Monsanto, Rafael
AU - Erdil, Mehmet
AU - Pauna, Henrique F.
AU - Kwon, Geeyoun
AU - Schachern, Patricia A.
AU - Tsuprun, Vladimir
AU - Paparella, Michael M.
AU - Cureoglu, Sebahattin
N1 - Publisher Copyright:
© Official journal of the American Academy of Otolaryngology-Head and Neck Surgery Foundation.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Objective To evaluate the histopathologic changes of dark, transitional, and hair cells of the vestibular system in human temporal bones from patients with chronic otitis media. Study Design Comparative human temporal bone study. Setting Otopathology laboratory. Subjects and Methods To compare the density of vestibular dark, transitional, and hair cells in temporal bones with and without chronic otitis media, we used differential interference contrast microscopy. Results In the chronic otitis media group (as compared with the age-matched control group), the density of type I and type II hair cells was significantly decreased in the lateral semicircular canal, saccule, and utricle (P <.05). The density of type I cells was also significantly decreased in the chronic otitis media group in the posterior semicircular canal (P =.005), but that of type II cells was not (P =.168). The mean number of dark cells was significantly decreased in the chronic otitis media group in the lateral semicircular canal (P =.014) and in the posterior semicircular canal (P =.002). We observed no statistically significant difference in the density of transitional cells between the 2 groups (P >.1). Conclusion The findings of our study suggest that the decrease in the number of vestibular sensory cells and dark cells could be the cause of the clinical symptoms of imbalance of some patients with chronic otitis media.
AB - Objective To evaluate the histopathologic changes of dark, transitional, and hair cells of the vestibular system in human temporal bones from patients with chronic otitis media. Study Design Comparative human temporal bone study. Setting Otopathology laboratory. Subjects and Methods To compare the density of vestibular dark, transitional, and hair cells in temporal bones with and without chronic otitis media, we used differential interference contrast microscopy. Results In the chronic otitis media group (as compared with the age-matched control group), the density of type I and type II hair cells was significantly decreased in the lateral semicircular canal, saccule, and utricle (P <.05). The density of type I cells was also significantly decreased in the chronic otitis media group in the posterior semicircular canal (P =.005), but that of type II cells was not (P =.168). The mean number of dark cells was significantly decreased in the chronic otitis media group in the lateral semicircular canal (P =.014) and in the posterior semicircular canal (P =.002). We observed no statistically significant difference in the density of transitional cells between the 2 groups (P >.1). Conclusion The findings of our study suggest that the decrease in the number of vestibular sensory cells and dark cells could be the cause of the clinical symptoms of imbalance of some patients with chronic otitis media.
KW - chronic otitis media
KW - dark cells
KW - dizziness
KW - hair cells
KW - histopathology
KW - temporal bone
KW - transitional cells
KW - vertigo
KW - vestibule
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U2 - 10.1177/0194599816646359
DO - 10.1177/0194599816646359
M3 - Article
C2 - 27165677
AN - SCOPUS:84984870851
SN - 0194-5998
VL - 155
SP - 494
EP - 500
JO - Otolaryngology - Head and Neck Surgery (United States)
JF - Otolaryngology - Head and Neck Surgery (United States)
IS - 3
ER -