TY - JOUR
T1 - Pathophysiology of congestive heart failure
AU - Francis, G. S Gary S
AU - Tang, W. H W
PY - 2003/6/23
Y1 - 2003/6/23
N2 - Heart failure is a clinical syndrome characterized by impaired structure and/or function of the heart, leading to dyspnea and fatigue at rest or with exertion. The pathophysiology of heart failure is complex, and there is no single lesion. Any form of heart disease can lead to heart failure. Most heart failure can be explained by well-recognized etiologic factors, though ostensibly healthy patients may harbor risk factors for the later development of heart failure. A fundamental response to myocardial injury or altered loading conditions includes "remodeling" of the heart, so that the size, shape, and flunction of the affected chamber is grossly distorted. This is accompanied by a constellation of biologic changes, best recognized in advanced cases of heart failure. These multiple alterations may be primary or secondary events but, nonetheless, add importantly to the morbidity and mortality of the patients. More emphasis should be placed on recognition and correction of risk factors related to the development of heart failure.
AB - Heart failure is a clinical syndrome characterized by impaired structure and/or function of the heart, leading to dyspnea and fatigue at rest or with exertion. The pathophysiology of heart failure is complex, and there is no single lesion. Any form of heart disease can lead to heart failure. Most heart failure can be explained by well-recognized etiologic factors, though ostensibly healthy patients may harbor risk factors for the later development of heart failure. A fundamental response to myocardial injury or altered loading conditions includes "remodeling" of the heart, so that the size, shape, and flunction of the affected chamber is grossly distorted. This is accompanied by a constellation of biologic changes, best recognized in advanced cases of heart failure. These multiple alterations may be primary or secondary events but, nonetheless, add importantly to the morbidity and mortality of the patients. More emphasis should be placed on recognition and correction of risk factors related to the development of heart failure.
KW - Cardiac myocyte hypertrophy
KW - Dilated cardiomyopathy
KW - Heart failure
KW - Systolic dysfunction
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M3 - Review article
C2 - 12776009
AN - SCOPUS:0038516688
SN - 1530-6550
VL - 4
SP - S14-S20
JO - Reviews in Cardiovascular Medicine
JF - Reviews in Cardiovascular Medicine
IS - SUPPL. 2
ER -