Patient-specific three-dimensional computational heart modeling and printing to enhance clinical understandings and treatment planning: Congenital recurrent pulmonary artery stenosis and transcatheter pulmonary valve replacement

Amanda C. Tenhoff, Varun Aggarwal, Rebecca Ameduri, Alex Deakyne, Tinen L. Iles, Sameh M. Said, Massimo Griselli, Paul A. Iaizzo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Advances in the surgical and interventional management of children with congenital heart disease has improved survival and outcomes. Each such patient is born with specific anatomical variations which call for detailed evaluations so to plan for appropriate patient-specific management. Significant progress has been made in commercially available two-dimensional imaging - i.e. echocardiogram, CT, and MRI - yet using such, three-dimensional anatomical details can be difficult to accurately represent. In addressing this concern, it has been shown that patient-specific three-dimensional modeling can be useful for interventional procedural or surgical planning [1]. Here we present two cases for which patient-specific anatomical three-dimensional modeling and printing were utilized for (1) the pre-sizing and placement of stents within a complex bifurcation pulmonary artery stenosis; and (2) evaluating the candidacy of the patient's anatomy for a transcatheter pulmonary valve placement. Detailed within this technical brief are de-identified case information, workflows for model generations, and results regarding clinical usage. In conclusion, we found these patient-specific models to be an advantageous resource for treatment planning in these two pediatric congenital heart disease cases.

Original languageEnglish (US)
Title of host publicationProceedings of the 2021 Design of Medical Devices Conference, DMD 2021
PublisherAmerican Society of Mechanical Engineers
ISBN (Electronic)9780791884812
DOIs
StatePublished - 2021
Event2021 Design of Medical Devices Conference, DMD 2021 - Virtual, Online
Duration: Apr 12 2021Apr 15 2021

Publication series

NameProceedings of the 2021 Design of Medical Devices Conference, DMD 2021

Conference

Conference2021 Design of Medical Devices Conference, DMD 2021
CityVirtual, Online
Period4/12/214/15/21

Bibliographical note

Funding Information:
We would like to thank the Visible Heart® Laboratories for their resources and expertise, as well as the University of Minnesota Masonic Children’s Hospital pediatric cardiac care team for their continuing collaborative efforts and dedication to improving pediatric healthcare. We would also like to thank Jesse Roitenberg, Scott Drikakis, and Evan Hochstein from Stratasys© for their expertise and assistance with printing. This research was made possible through support from the Institute for Engineering in Medicine and unrestricted educational grants from Stratasys© for 3D printing.

Publisher Copyright:
© 2021 by ASME.

Keywords

  • 3D printing
  • Congenital heart disease (CHD)
  • Patient-specific 3D modeling
  • Pediatrics
  • Pulmonary artery stenosis
  • TPVR
  • Tetralogy of Fallot (TOF)

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