Patterns of farm exposure are associated with reduced incidence of atopic dermatitis in early life

Cheryl A. Steiman, Michael D. Evans, Kristine E. Lee, Michael R. Lasarev, Ronald E. Gangnon, Brent F. Olson, Kathrine L. Barnes, Casper G. Bendixsen, Christine M. Seroogy, James E. Gern

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Farm exposures may reduce the risk of atopic dermatitis (AD) in children, but this is controversial and US data are limited. Objective: This study was conducted to identify patterns of farm exposure in Wisconsin family farms that modify AD incidence and prevalence in early childhood. Methods: Environmental exposures, health history, and clinical outcomes were prospectively recorded for 111 farm families and 129 non–farm families enrolled in the Wisconsin Infant Study Cohort birth cohort study. Exposures from the prenatal and early postnatal (2-month) visits were evaluated together with parental report of AD diagnosis by a health care provider through age 24 months. Latent class analysis was performed with prenatal and early postnatal farm-exposure variables to assign farm children to 3 classes. Results: Overall, children of farm families had reduced AD incidence (P =.03). Within farm families, exposures including poultry (3% vs 28%; P =.003), pig (4% vs 25%; P =.04), feed grain (13% vs 34%; P =.02), and number of animal species were inversely associated with AD incidence. Among the latent class groups, children in families with diverse or more intense farm exposures (classes A and B) had reduced AD incidence, whereas low-exposure (class C) infants had AD incidence similar to that in nonfarm children. Conclusions: Infants in Wisconsin farm families had reduced AD incidence, and patterns of farm exposures further defined AD risk. These findings suggest that exposure to diverse farm animals, feed, and bedding during the prenatal period and in early infancy reduce the risk of early-onset AD, a phenotype associated with multiple other atopic diseases.

Original languageEnglish (US)
Pages (from-to)1379-1386.e6
JournalJournal of Allergy and Clinical Immunology
Volume146
Issue number6
DOIs
StatePublished - Dec 2020
Externally publishedYes

Bibliographical note

Funding Information:
All study activities and procedures were approved by the Marshfield Clinic Research Institute (KEI10613) and University of Wisconsin-Madison (2012-1056) Human Subjects Institutional Review Boards.This study was funded by the National Institutes of Health (NIH)-National Institute of Allergy and Infectious Diseases (grant nos. U19 AI104317 and 5T32AI007635-18), NIH-National Center for Advancing Translational Sciences (grant no. UL1TR000427), NIH Office of the Director (grant no. UG3/UH3 OD023282), and the Marshfield Clinic Research Institute.

Keywords

  • Atopic dermatitis
  • birth cohort
  • children
  • farm effect
  • latent class analysis

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