TY - JOUR
T1 - Peak bone mass from longitudinal data
T2 - Implications for the prevalence, pathophysiology, and diagnosis of osteoporosis
AU - Berger, Claudie
AU - Goltzman, David
AU - Langsetmo, Lisa
AU - Joseph, Lawrence
AU - Jackson, Stuart
AU - Kreiger, Nancy
AU - Tenenhouse, Alan
AU - Davison, K. Shawn
AU - Josse, Robert G.
AU - Prior, Jerilynn C.
AU - Hanley, David A.
AU - Poliquin, Suzette
AU - Godmaire, Suzanne
AU - Joyce, Carol
AU - Kovacs, Christopher
AU - Sheppard, Emma
AU - Kirkland, Susan
AU - Kaiser, Stephanie
AU - Stanfield, Barbara
AU - Brown, Jacques P.
AU - Bessette, Louis
AU - Gendreau, Marc
AU - Anastassiades, Tassos
AU - Towheed, Tanveer
AU - Matthews, Barbara
AU - Josse, Bob
AU - Jamal, Sophie
AU - Murray, Tim
AU - Gardner-Bray, Barbara
AU - Adachi, Jonathan D.
AU - Papaioannou, Alexandra
AU - Pickard, Laura
AU - Olszynski, Wojciech P.
AU - Thingvold, Jola
AU - Allan, Jane
AU - Patel, Millan
AU - Lentle, Brian
AU - Vigna, Yvette
PY - 2010/9
Y1 - 2010/9
N2 - We estimated peak bone mass (PBM) in 615 women and 527 men aged 16 to 40 years using longitudinal data from the Canadian Multicentre Osteoporosis Study (CaMos). Individual rates of change were averaged to find the mean rate of change for each baseline age. The age range for PBM was defined as the period during which bone mineral density (BMD) was stable. PBM was estimated via hierarchical models, weighted according to 2006 Canadian Census data. Lumbar spine PBM (1.046 ± 0.123 g/cm2) occurred at ages 33 to 40 years in women and at 19 to 33 years in men (1.066 ± 0.129 g/cm 2). Total hip PBM (0.981 ± 0.122 g/cm2) occurred at ages 16 to 19 years in women and 19 to 21 years in men (1.093 ± 0.169 g/cm2). Analysis of Canadian geographic variation revealed that the levels of PBM and of mean BMD in those over age 65 sometimes were discordant, suggesting that PBM and subsequent rates of bone loss may be subject to different genetic and/or environmental influences. Based on our longitudinally estimated PBM values, the estimated Canadian prevalences of osteoporosis (T-score<-2.5) were 12.0% (L1-L4) and 9.1% (total hip) in women aged 50 years and older and 2.9% (L1-L4) and 0.9% (total hip) in men aged 50 years and older. These were higher than prevalences using cross-sectional PBM data. In summary, we found that the age at which PBM is achieved varies by sex and skeletal site, and different reference values for PBM lead to different estimates of the prevalence of osteoporosis. Furthermore, lack of concordance of PBM and BMD over age 65 suggests different determinants of PBM and subsequent bone loss.
AB - We estimated peak bone mass (PBM) in 615 women and 527 men aged 16 to 40 years using longitudinal data from the Canadian Multicentre Osteoporosis Study (CaMos). Individual rates of change were averaged to find the mean rate of change for each baseline age. The age range for PBM was defined as the period during which bone mineral density (BMD) was stable. PBM was estimated via hierarchical models, weighted according to 2006 Canadian Census data. Lumbar spine PBM (1.046 ± 0.123 g/cm2) occurred at ages 33 to 40 years in women and at 19 to 33 years in men (1.066 ± 0.129 g/cm 2). Total hip PBM (0.981 ± 0.122 g/cm2) occurred at ages 16 to 19 years in women and 19 to 21 years in men (1.093 ± 0.169 g/cm2). Analysis of Canadian geographic variation revealed that the levels of PBM and of mean BMD in those over age 65 sometimes were discordant, suggesting that PBM and subsequent rates of bone loss may be subject to different genetic and/or environmental influences. Based on our longitudinally estimated PBM values, the estimated Canadian prevalences of osteoporosis (T-score<-2.5) were 12.0% (L1-L4) and 9.1% (total hip) in women aged 50 years and older and 2.9% (L1-L4) and 0.9% (total hip) in men aged 50 years and older. These were higher than prevalences using cross-sectional PBM data. In summary, we found that the age at which PBM is achieved varies by sex and skeletal site, and different reference values for PBM lead to different estimates of the prevalence of osteoporosis. Furthermore, lack of concordance of PBM and BMD over age 65 suggests different determinants of PBM and subsequent bone loss.
KW - Geographic variation
KW - Longitudinal
KW - Osteoporosis prevalence
KW - Peak bone mass
KW - T-scores
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U2 - 10.1002/jbmr.95
DO - 10.1002/jbmr.95
M3 - Article
C2 - 20499378
AN - SCOPUS:77956816705
SN - 0884-0431
VL - 25
SP - 1948
EP - 1957
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
IS - 9
ER -