Pectin in biomedical and drug delivery applications: A review

De qiang Li, Jun Li, Hui lin Dong, Xin Li, Jia qi Zhang, Shri Ramaswamy, Feng Xu

Research output: Contribution to journalReview articlepeer-review

Abstract

Natural macromolecules have attracted increasing attention due to their biocompatibility, low toxicity, and biodegradability. Pectin is one of the few polysaccharides with biomedical activity, consequently a candidate in biomedical and drug delivery Applications. Rhamnogalacturonan-II, a smaller component in pectin, plays a major role in biomedical activities. The ubiquitous presence of hydroxyl and carboxyl groups in pectin contribute to their hydrophilicity and, hence, to the favorable biocompatibility, low toxicity, and biodegradability. However, pure pectin-based materials present undesirable swelling and corrosion properties. The hydrophilic groups, via coordination, electrophilic addition, esterification, transesterification reactions, can contribute to pectin's physicochemical properties. Here the properties, extraction, and modification of pectin, which are fundamental to biomedical and drug delivery applications, are reviewed. Moreover, the synthesis, properties, and performance of pectin-based hybrid materials, composite materials, and emulsions are elaborated. The comprehensive review presented here can provide valuable information on pectin and its biomedical and drug delivery applications.

Original languageEnglish (US)
Pages (from-to)49-65
Number of pages17
JournalInternational Journal of Biological Macromolecules
Volume185
DOIs
StatePublished - Aug 31 2021

Bibliographical note

Funding Information:
The present work was supported by the National Natural Science Foundation of China (NO. 21664013 ), Natural Science Foundation of Xinjiang, China (NO. 2021D01A74 , NO. 2019D01A54 ), World-Class Discipline Construction and Characteristic Development Guidance Funds for Beijing Forestry University (NO. 2019XKJS0330 ), Higher Educational Science and Technology Program of Xinjiang , China (NO. XJEDU2019Y021 ).

Funding Information:
The present work was supported by the National Natural Science Foundation of China (NO. 21664013), Natural Science Foundation of Xinjiang, China (NO. 2021D01A74, NO. 2019D01A54), World-Class Discipline Construction and Characteristic Development Guidance Funds for Beijing Forestry University (NO. 2019XKJS0330), Higher Educational Science and Technology Program of Xinjiang, China (NO. XJEDU2019Y021).

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

  • Biomedical applications
  • Composite materials
  • Drug delivery
  • Hybrid materials
  • Modification
  • Pectin

PubMed: MeSH publication types

  • Journal Article
  • Review

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