Peptide targeted lipid nanoparticles for anticancer drug delivery

Kamlesh Shroff, Timothy R Pearce, Efie Kokkoli

Research output: Contribution to journalReview articlepeer-review

134 Scopus citations

Abstract

Encapsulating anticancer drugs in nanoparticles has proven to be an effective mechanism to alter the pharmacokinetic and pharmacodynamic profi les of the drugs, leading to clinically useful cancer therapeutics like Doxil and DaunoXome. Underdeveloped tumor vasculature and lymphatics allow these fi rst-generation nanoparticles to passively accumulate within the tumor, but work to create the next-generation nanoparticles that actively participate in the tumor targeting process is underway. Lipid nanoparticles functionalized with targeting peptides are among the most often studied. The goal of this article is to review the recently published literature of targeted nanoparticles to highlight successful designs that improved in vivo tumor therapy, and to discuss the current challenges of designing these nanoparticles for effective in vivo performance.

Original languageEnglish (US)
Pages (from-to)3803-3822
Number of pages20
JournalAdvanced Materials
Volume24
Issue number28
DOIs
StatePublished - Jul 24 2012

Keywords

  • cancer
  • drug delivery
  • lipid nanoparticles
  • liposomes
  • peptides

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