Peptide YY (PYY) enhances feeding and drinking more potently than does neuropeptide Y after central administration. Chronic administration of PYY every 6 h for 48 h causes massive food ingestion. Tolerance to this effect of PYY does not appear to develop. This data suggests that PYY is one of the most potent orexigenic substances yet to be identified. PYY may play a role in the pathogenesis of bulimic syndromes.
Bibliographical noteFunding Information:
We acknowledge the excellent secretarial assistance of J. Tallman. The studies reported here were supported by the Medical Research Funds of the Veterans Administration.
Copyright 2014 Elsevier B.V., All rights reserved.
- food intake
- peptide YY