Peptidergic regulation of norepinephrine induced feeding

John E. Morley, Allen S. Levine, Samuel S. Murray, Julie Kneip

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

The inhibitory effect of a variety of substances on feeding induced by norepinephrine (20 μg ICV) was studied. Subcutaneous administration of the opiate antagonist, naloxone, inhibited norepinephrine-induced eating at 10 and 5 mg/kg, but not a 1 mg/kg. Intraventricular administration of the GABA antagonist, bicuculline, produced a dose related decrease in food ingestion. The putative satiety hormones, bombesin (10 μg/kg; subcutaneously) and cholecystokinin octapeptide ( 10 gmg/kg; subcutaneously) also reduced norepinephrine induced eating, as did ICV administration of calcitonin (2 units). Neither thyrotropin-releasing hormone (1 μg ICV) nor its metabolits, histidyl-proline diketopiperazine (1 μg ICV) altered norepinephrine-induced feeding. The studies reported here suggest a neuromodulatory role of peptides in the central regulation of norepinephrine-induced feeding.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume16
Issue number2
DOIs
StatePublished - Feb 1982

Keywords

  • Appetite
  • Bicuculline
  • Bombesin
  • Cholecystokinin
  • GABA
  • Histidyl-proline diketopiperazine
  • Naloxone
  • Norepinephrine
  • Opiates
  • TRH

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