TY - JOUR
T1 - Per- and polyfluoroalkyl substances (PFAS) in American Red Cross adult blood donors, 2000–2015
AU - Olsen, Geary W.
AU - Mair, David C.
AU - Lange, Cleston C.
AU - Harrington, Laura M.
AU - Church, Timothy R.
AU - Goldberg, Corinne L.
AU - Herron, Ross M.
AU - Hanna, Hank
AU - Nobiletti, John B.
AU - Rios, Jorge A.
AU - Reagen, William K.
AU - Ley, Carol A.
N1 - Publisher Copyright:
© 2017 The Authors
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017
Y1 - 2017
N2 - In 2015, thirteen per- and polyfluoroalkyl substances (PFAS), including perfluorohexanesulfonate (PFHxS), perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), and perfluorodecanoate (PFDA) were analyzed in human plasma that was collected from a total of 616 American Red Cross male and female blood donors (ages 20–69) at 6 regional blood collection centers. Plasma samples were analyzed using a validated solvent precipitation-isotope dilution direction-liquid chromatography tandem mass spectrometry method. The data were analyzed in conjunction with prior cross-sectional investigations [2000–2001 (n =645), 2006 (n =600), and 2010 (n =600) to determine PFAS trends. Age- and sex-adjusted geometric mean serum (2000–2001) and plasma (2006, 2010, 2015) concentrations (ng/mL) were, respectively: PFHxS (2.3, 1.5, 1.3, 0.9); PFOS (35.1, 14.5, 8.4, 4.3); PFOA (4.7, 3.4, 2.4, 1.1); PFNA (0.6, 1.0, 0.8, 0.4); and PFDA (0.2, 0.3, 0.3, 0.1). The percentage decline in these age- and sex-adjusted geometric mean concentrations from 2000–2001 to 2015 were: PFHxS (61%); PFOS (88%); PFOA (77%); PFNA (33%); and PFDA (50%). The results indicate a continued decline of PFHxS, PFOS, and PFOA concentrations in American Red Cross blood donors. For the remaining PFAS measured in 2015, including the shorter chain perfluoroalkyls perfluorobutanesulfonate (PFBS) and perfluorohexanoate (PFHxA), the majority of samples were below the lower limit of quantitation.
AB - In 2015, thirteen per- and polyfluoroalkyl substances (PFAS), including perfluorohexanesulfonate (PFHxS), perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), and perfluorodecanoate (PFDA) were analyzed in human plasma that was collected from a total of 616 American Red Cross male and female blood donors (ages 20–69) at 6 regional blood collection centers. Plasma samples were analyzed using a validated solvent precipitation-isotope dilution direction-liquid chromatography tandem mass spectrometry method. The data were analyzed in conjunction with prior cross-sectional investigations [2000–2001 (n =645), 2006 (n =600), and 2010 (n =600) to determine PFAS trends. Age- and sex-adjusted geometric mean serum (2000–2001) and plasma (2006, 2010, 2015) concentrations (ng/mL) were, respectively: PFHxS (2.3, 1.5, 1.3, 0.9); PFOS (35.1, 14.5, 8.4, 4.3); PFOA (4.7, 3.4, 2.4, 1.1); PFNA (0.6, 1.0, 0.8, 0.4); and PFDA (0.2, 0.3, 0.3, 0.1). The percentage decline in these age- and sex-adjusted geometric mean concentrations from 2000–2001 to 2015 were: PFHxS (61%); PFOS (88%); PFOA (77%); PFNA (33%); and PFDA (50%). The results indicate a continued decline of PFHxS, PFOS, and PFOA concentrations in American Red Cross blood donors. For the remaining PFAS measured in 2015, including the shorter chain perfluoroalkyls perfluorobutanesulfonate (PFBS) and perfluorohexanoate (PFHxA), the majority of samples were below the lower limit of quantitation.
KW - Biomonitoring
KW - PFHxS
KW - PFOA
KW - PFOS
KW - Perfluoroalkyls
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U2 - 10.1016/j.envres.2017.05.013
DO - 10.1016/j.envres.2017.05.013
M3 - Article
C2 - 28528142
AN - SCOPUS:85019501687
SN - 0013-9351
VL - 157
SP - 87
EP - 95
JO - Environmental Research
JF - Environmental Research
ER -