Abstract
Background: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions. Methods: This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer–Lemeshow test). Results: Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71–0.81) and the Hosmer–Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1. Conclusions: In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.
| Original language | English (US) |
|---|---|
| Article number | 98 |
| Journal | Annals of Intensive Care |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 1 2016 |
Keywords
- Children
- Critical care
- Multiple organ failure
- Outcome
- Plasma transfusion
- Score
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Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions. / Karam, Oliver; Demaret, Pierre; Duhamel, Alain; Shefler, Alison; Spinella, Philip C.; Stanworth, Simon J.; Tucci, Marisa; Leteurtre, Stéphane; for the PlasmaTV investigators, the PlasmaTV investigators; Butt, Warwick; Delzoppo, Carmel; Bain, Kym; Erickson, Simon; Smalley, Nathan; Dorofaeff, Tavey; Long, Debbie; Wiseman, Greg; Clénent de Cléty, Stéphan; Berghe, Caroline; de Jaeger, Annick; Demaret, Pierre; Trippaerts, Marc; Willems, Ariane; Rooze, Shancy; De Dooy, Jozef; Gilfoyle, Elaine; Wohlgemuth, Lynette; Tucci, Marisa; Dumitrascu, Mariana; Withington, Davinia; Hickey, Julia; Choong, Karen; Sanders, Lois; Morrison, Gavin; Tijssen, Janice; Wensley, David; Krahn, Gordon; Dugas, Marc Andre; Gosselin, Louise; Santschi, Miriam; Von Dessauer, Bettina; Ordenes, Nadia; Afshari, Arash; Andersen, Lasse Hoegh; Nilsson, Jens Christian; Johansen, Mathias; Baek Jensen, Anne Mette; Campos Mino, Santiago; Grunauer, Michelle; Joram, Nicolas; Roullet-Renoleau, Nicolas; Javouhey, Etienne; Cour-Andlauer, Fleur; Portefaix, Aurélie; Brissaud, Olivier; Guichoux, Julie; Payen, Valérie; Léger, Pierre Louis; Afanetti, Mickael; Mortamet, Guillaume; Maria, Matthieu; Breining, Audrey; Tissieres, Pierre; Dorkenoo, Aimée; Deho, Anna; Steinherr, Harry; Nikolaou, Filippia; Camporesi, Anna; Mario, Federica; Kawasaki, Tatsuya; Miura, Shinya; Beca, John; Rea, Miriam; Sherring, Claire; Bushell, Tracey; Bentsen, Gunnar; Dinis, Alexandra; Pereira, Gabriela; Vieira, Marisa; Moniz, Marta; Alshehri, Saleh; Alasnag, Manal; Pisarcikova, Maria; Jordan, Iolanda; Balcells, Joan; Perez-Ferrer, Antonio; de Vicente Sánchez, Jesús; Vazquez Moyano, Marta; Morales Martinez, Antonio; Lopez-Herce, Jesus; Solana, Maria Jose; Flores González, Jose Carlos; Alonso, Maria Teresa; Nieto Faza, Manuel; Perez, Marie Hélène; Amiet, Vivianne; Doell, Carsten; Bordessoule, Alice; Cochius-den Otter, Suzan; Kapitein, Berber; Kneyber, Martin; Brierley, Joe; Rea, Vanessa; McKeever, Stephen; Kelleher, Andrea; Scholefield, Barney; Top, Anke; Kelly, Nicola; Virdee, Satnam; Davis, Peter; George, Susan; Hawkins, Kay C.; McCall, Katie; Brown, Victoria; Sykes, Kim; Levin, Richard; MacLeod, Isobel; Horan, Marie; Jirasek, Petr; Inwald, David; Abdulla, Amina; Raghunanan, Sophie; Taylor, Bob; Shefler, Alison; Sparkes, Hannah; Hanson, Sheila; Woods, Katherine; Triscari, David; Murkowski, Kathy; Ozment, Caroline; Steiner, Marie; Nerheim, Dan; Galster, Amanda; Higgerson, Renee; Christie, Lee Ann; Spinella, Philip C.; Martin, Daniel; Rourke, Liz; Muszynski, Jennifer; Steele, Lisa; Ajizian, Samuel; McCrory, Michael C.; O’Brien, Kevin; Babbitt, Christopher; Felkel, Erin; Levine, Glenn; Truemper, Edward J.; Zink, Machelle; Nellis, Marianne; Thomas, Neal J.; Spear, Debbie; Markovitz, Barry; Terry, Jeff; Morzov, Rica; Montgomery, Vicki; Michael, Andrew; Thomas, Melissa; Singleton, Marcy; Jarvis, Dean; Nett, Sholeen; Willson, Douglas; Hoot, Michelle; Bembea, Melania; Yiu, Alvin; McKinley, David; Scarlett, Elizabeth; Sankey, Jennifer; Parikh, Minal; Vincent, E.; Faustino, S.; Michelson, Kelly; Rilinger, Jay; Campbell, Laura; Gertz, Shira; Cholette, Jill M.; Jeyapalan, Asumthia; Parker, Margaret; Bateman, Scot; Johnson, Amanda.
In: Annals of Intensive Care, Vol. 6, No. 1, 98, 01.12.2016.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions
AU - Karam, Oliver
AU - Demaret, Pierre
AU - Duhamel, Alain
AU - Shefler, Alison
AU - Spinella, Philip C.
AU - Stanworth, Simon J.
AU - Tucci, Marisa
AU - Leteurtre, Stéphane
AU - for the PlasmaTV investigators, the PlasmaTV investigators
AU - Butt, Warwick
AU - Delzoppo, Carmel
AU - Bain, Kym
AU - Erickson, Simon
AU - Smalley, Nathan
AU - Dorofaeff, Tavey
AU - Long, Debbie
AU - Wiseman, Greg
AU - Clénent de Cléty, Stéphan
AU - Berghe, Caroline
AU - de Jaeger, Annick
AU - Demaret, Pierre
AU - Trippaerts, Marc
AU - Willems, Ariane
AU - Rooze, Shancy
AU - De Dooy, Jozef
AU - Gilfoyle, Elaine
AU - Wohlgemuth, Lynette
AU - Tucci, Marisa
AU - Dumitrascu, Mariana
AU - Withington, Davinia
AU - Hickey, Julia
AU - Choong, Karen
AU - Sanders, Lois
AU - Morrison, Gavin
AU - Tijssen, Janice
AU - Wensley, David
AU - Krahn, Gordon
AU - Dugas, Marc Andre
AU - Gosselin, Louise
AU - Santschi, Miriam
AU - Von Dessauer, Bettina
AU - Ordenes, Nadia
AU - Afshari, Arash
AU - Andersen, Lasse Hoegh
AU - Nilsson, Jens Christian
AU - Johansen, Mathias
AU - Baek Jensen, Anne Mette
AU - Campos Mino, Santiago
AU - Grunauer, Michelle
AU - Joram, Nicolas
AU - Roullet-Renoleau, Nicolas
AU - Javouhey, Etienne
AU - Cour-Andlauer, Fleur
AU - Portefaix, Aurélie
AU - Brissaud, Olivier
AU - Guichoux, Julie
AU - Payen, Valérie
AU - Léger, Pierre Louis
AU - Afanetti, Mickael
AU - Mortamet, Guillaume
AU - Maria, Matthieu
AU - Breining, Audrey
AU - Tissieres, Pierre
AU - Dorkenoo, Aimée
AU - Deho, Anna
AU - Steinherr, Harry
AU - Nikolaou, Filippia
AU - Camporesi, Anna
AU - Mario, Federica
AU - Kawasaki, Tatsuya
AU - Miura, Shinya
AU - Beca, John
AU - Rea, Miriam
AU - Sherring, Claire
AU - Bushell, Tracey
AU - Bentsen, Gunnar
AU - Dinis, Alexandra
AU - Pereira, Gabriela
AU - Vieira, Marisa
AU - Moniz, Marta
AU - Alshehri, Saleh
AU - Alasnag, Manal
AU - Pisarcikova, Maria
AU - Jordan, Iolanda
AU - Balcells, Joan
AU - Perez-Ferrer, Antonio
AU - de Vicente Sánchez, Jesús
AU - Vazquez Moyano, Marta
AU - Morales Martinez, Antonio
AU - Lopez-Herce, Jesus
AU - Solana, Maria Jose
AU - Flores González, Jose Carlos
AU - Alonso, Maria Teresa
AU - Nieto Faza, Manuel
AU - Perez, Marie Hélène
AU - Amiet, Vivianne
AU - Doell, Carsten
AU - Bordessoule, Alice
AU - Cochius-den Otter, Suzan
AU - Kapitein, Berber
AU - Kneyber, Martin
AU - Brierley, Joe
AU - Rea, Vanessa
AU - McKeever, Stephen
AU - Kelleher, Andrea
AU - Scholefield, Barney
AU - Top, Anke
AU - Kelly, Nicola
AU - Virdee, Satnam
AU - Davis, Peter
AU - George, Susan
AU - Hawkins, Kay C.
AU - McCall, Katie
AU - Brown, Victoria
AU - Sykes, Kim
AU - Levin, Richard
AU - MacLeod, Isobel
AU - Horan, Marie
AU - Jirasek, Petr
AU - Inwald, David
AU - Abdulla, Amina
AU - Raghunanan, Sophie
AU - Taylor, Bob
AU - Shefler, Alison
AU - Sparkes, Hannah
AU - Hanson, Sheila
AU - Woods, Katherine
AU - Triscari, David
AU - Murkowski, Kathy
AU - Ozment, Caroline
AU - Steiner, Marie
AU - Nerheim, Dan
AU - Galster, Amanda
AU - Higgerson, Renee
AU - Christie, Lee Ann
AU - Spinella, Philip C.
AU - Martin, Daniel
AU - Rourke, Liz
AU - Muszynski, Jennifer
AU - Steele, Lisa
AU - Ajizian, Samuel
AU - McCrory, Michael C.
AU - O’Brien, Kevin
AU - Babbitt, Christopher
AU - Felkel, Erin
AU - Levine, Glenn
AU - Truemper, Edward J.
AU - Zink, Machelle
AU - Nellis, Marianne
AU - Thomas, Neal J.
AU - Spear, Debbie
AU - Markovitz, Barry
AU - Terry, Jeff
AU - Morzov, Rica
AU - Montgomery, Vicki
AU - Michael, Andrew
AU - Thomas, Melissa
AU - Singleton, Marcy
AU - Jarvis, Dean
AU - Nett, Sholeen
AU - Willson, Douglas
AU - Hoot, Michelle
AU - Bembea, Melania
AU - Yiu, Alvin
AU - McKinley, David
AU - Scarlett, Elizabeth
AU - Sankey, Jennifer
AU - Parikh, Minal
AU - Vincent, E.
AU - Faustino, S.
AU - Michelson, Kelly
AU - Rilinger, Jay
AU - Campbell, Laura
AU - Gertz, Shira
AU - Cholette, Jill M.
AU - Jeyapalan, Asumthia
AU - Parker, Margaret
AU - Bateman, Scot
AU - Johnson, Amanda
N1 - Publisher Copyright: © 2016, The Author(s). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Background: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions. Methods: This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer–Lemeshow test). Results: Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71–0.81) and the Hosmer–Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1. Conclusions: In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.
AB - Background: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions. Methods: This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer–Lemeshow test). Results: Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71–0.81) and the Hosmer–Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1. Conclusions: In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.
KW - Children
KW - Critical care
KW - Multiple organ failure
KW - Outcome
KW - Plasma transfusion
KW - Score
UR - http://www.scopus.com/inward/record.url?scp=84991228902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991228902&partnerID=8YFLogxK
U2 - 10.1186/s13613-016-0197-6
DO - 10.1186/s13613-016-0197-6
M3 - Article
C2 - 27714707
AN - SCOPUS:84991228902
VL - 6
JO - Annals of Intensive Care
JF - Annals of Intensive Care
SN - 2110-5820
IS - 1
M1 - 98
ER -