TY - JOUR
T1 - Performance of the vibrating membrane aerosol generation device
T2 - Aeroneb micropump nebulizer™
AU - Zhang, Guifang
AU - David, Anand
AU - Wiedmann, Timothy Scott
PY - 2007/12/1
Y1 - 2007/12/1
N2 - The output and particle size distribution of several series of aqueous solutions were measured to define quantitatively the practical limits of the solution properties acceptable for aerosol production by the aeroneb micropump nebulizer. Aerosol output measurements were made gravimetrically and the particle size distributions were obtained by laser diffractometry. Solution properties were obtained from the literature by interpolation of the best-fit curve of the property plotted as a function of composition. For nonionic solutes, addition of sodium chloride dramatically increased the output rate and also decreased the droplet size at low solute concentrations. Increasing viscosity also caused a significant decrease in output. Cesium chloride displayed increased output rate with concentration due to the rising density. Based on calculations with the number of apertures and oscillatory frequency, low output rates appeared to be a consequence of apertures failing to produce a droplet with each oscillation. Overall, ionic strength, density, surface tension, and viscosity affected the output rate in a manner that can be now empirically predicted.
AB - The output and particle size distribution of several series of aqueous solutions were measured to define quantitatively the practical limits of the solution properties acceptable for aerosol production by the aeroneb micropump nebulizer. Aerosol output measurements were made gravimetrically and the particle size distributions were obtained by laser diffractometry. Solution properties were obtained from the literature by interpolation of the best-fit curve of the property plotted as a function of composition. For nonionic solutes, addition of sodium chloride dramatically increased the output rate and also decreased the droplet size at low solute concentrations. Increasing viscosity also caused a significant decrease in output. Cesium chloride displayed increased output rate with concentration due to the rising density. Based on calculations with the number of apertures and oscillatory frequency, low output rates appeared to be a consequence of apertures failing to produce a droplet with each oscillation. Overall, ionic strength, density, surface tension, and viscosity affected the output rate in a manner that can be now empirically predicted.
KW - Aeroneb micropump nebulizer
KW - Aerosol
KW - Cancer prevention
KW - Density
KW - Surface tension
KW - Vibrating membrane
KW - Viscosity
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U2 - 10.1089/jam.2007.0622
DO - 10.1089/jam.2007.0622
M3 - Article
C2 - 18158713
AN - SCOPUS:37549027163
SN - 0894-2684
VL - 20
SP - 408
EP - 416
JO - Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung
JF - Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung
IS - 4
ER -