TY - JOUR
T1 - Perioperative complications and outcome after surgery for treatment of gastric carcinoma in dogs
T2 - A Veterinary Society of Surgical Oncology retrospective study of 40 cases (2004–2018)
AU - Abrams, Brittany
AU - Wavreille, Vincent A.
AU - Husbands, Brian D.
AU - Matz, Brad M.
AU - Massari, Federico
AU - Liptak, Julius M.
AU - Cray, Megan T.
AU - de Mello Souza, Carlos Henrique
AU - Wustefeld-Janssens, Brandan G.
AU - Oblak, Michelle L.
AU - Su, Lillian
AU - Selmic, Laura E.
N1 - Publisher Copyright:
© 2019 The American College of Veterinary Surgeons
PY - 2019
Y1 - 2019
N2 - Objective: To describe the clinical characteristics, perioperative complications, and outcomes in dogs surgically treated for gastric carcinoma. Study design: Multi-institutional retrospective case series. Animals: Forty client-owned dogs with histologically confirmed gastric carcinoma. Methods: Medical records were reviewed for preoperative diagnostics, surgery, histopathology, postoperative complications, adjuvant chemotherapy, disease progression, and survival. Variables were assessed for associations with outcome by using Cox proportional hazards regression analysis. Results: Surgical treatment included partial gastrectomy (28 dogs), Billroth I (9 dogs), subtotal gastrectomy (2 dogs), and submucosal resection (1 dog). Major postoperative complications occurred in 8 of 40 dogs, including septic peritonitis secondary to dehiscence in 4 dogs. The median progression free interval was 54 days, and the median survival time (MST) was 178 days (range, 1–1902). According to multivariable analysis results, experiencing an intraoperative complication was associated with an increased risk of death (hazard ratio [HR] 3.5, 95% CI 1.1–9.8, P =.005), and administration of adjuvant chemotherapy correlated with an improved survival (HR 0.4, 95% CI 0.2–0.9, P =.03). Conclusion: In this population of dogs, MST exceeded historically reported data, major postoperative complication rates were comparable to established literature, and administration of adjuvant chemotherapy was associated with improved survival. Clinical significance: Results from this study may be used to counsel owners more accurately regarding prognosis for dogs undergoing surgical excision for gastric carcinoma.
AB - Objective: To describe the clinical characteristics, perioperative complications, and outcomes in dogs surgically treated for gastric carcinoma. Study design: Multi-institutional retrospective case series. Animals: Forty client-owned dogs with histologically confirmed gastric carcinoma. Methods: Medical records were reviewed for preoperative diagnostics, surgery, histopathology, postoperative complications, adjuvant chemotherapy, disease progression, and survival. Variables were assessed for associations with outcome by using Cox proportional hazards regression analysis. Results: Surgical treatment included partial gastrectomy (28 dogs), Billroth I (9 dogs), subtotal gastrectomy (2 dogs), and submucosal resection (1 dog). Major postoperative complications occurred in 8 of 40 dogs, including septic peritonitis secondary to dehiscence in 4 dogs. The median progression free interval was 54 days, and the median survival time (MST) was 178 days (range, 1–1902). According to multivariable analysis results, experiencing an intraoperative complication was associated with an increased risk of death (hazard ratio [HR] 3.5, 95% CI 1.1–9.8, P =.005), and administration of adjuvant chemotherapy correlated with an improved survival (HR 0.4, 95% CI 0.2–0.9, P =.03). Conclusion: In this population of dogs, MST exceeded historically reported data, major postoperative complication rates were comparable to established literature, and administration of adjuvant chemotherapy was associated with improved survival. Clinical significance: Results from this study may be used to counsel owners more accurately regarding prognosis for dogs undergoing surgical excision for gastric carcinoma.
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U2 - 10.1111/vsu.13239
DO - 10.1111/vsu.13239
M3 - Article
C2 - 31140634
AN - SCOPUS:85066499516
SN - 0161-3499
VL - 48
SP - 923
EP - 932
JO - Veterinary Surgery
JF - Veterinary Surgery
IS - 6
ER -