Periovulatory female goldfish release three potential pheromones: 17α,20β-Dihydroxyprogesterone, 17α,20β-dihydroxyprogesterone glucuronide, and 17α-hydroxyprogesterone

G. Van Der Kraak, P. W. Sorensen, N. E. Stacey, J. G. Dulka

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Our previous studies have shown that 17α,20β-dihydroxy-4-pregnen-3-one (17,20β-P) produced by preovulatory female goldfish functions both as a hormone promoting oocyte final maturation and as a primer sex pheromone stimulating rapid reproductive endocrine responses in the male. In the present study, the amounts of free and glucuronated 17,20β-P as well as free 17α-hydroxyprogesterone (17P) released to the holding water by female goldfish throughout the periovulatory period were determined. Compared to nonovulating female goldfish, ovulating goldfish released very high levels of each of these steroids. This study confirmed that 17,20β-P is released to the water by ovulating fish in sufficient amounts to have pheromonal activity and indicated that 17P may also function as a pheromone. Although considerable quantities of 17,20β-P glucuronide were also released, its physiological actions are unknown.

Original languageEnglish (US)
Pages (from-to)452-457
Number of pages6
JournalGeneral and Comparative Endocrinology
Volume73
Issue number3
DOIs
StatePublished - Mar 1989

Bibliographical note

Funding Information:
Antisera to 17,2Op-P was provided by Dr. A. P. Scott. This work was funded by Grant A2903 from the Natural Sciences and Engineering Research Council of Canada to N.E.S., G.V.D.K., P.W.S., and J.G.D. were supported by the Alberta Heritage Foundation for Medical Research.

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