Persistence with growth hormone therapy in pediatric patients

Bradley S. Miller, Deborah Rotenstein, Larry C. Deeb, John Germak, Tami Wisniewski

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objectives: Height outcomes were assessed in children with idiopathic growth hormone deficiency (IGHD) and multiple pituitary hormone deficiency (MPHD) who discontinued growth hormone (GH) therapy. Study Design: Data were obtained from the American Norditropin Studies: Web-Enabled Research (ANSWER) Program/NovoNet for enrolled children who had discontinued therapy. Methods: Treatment duration (months), height velocity, and corrected height standard deviation score (HSDS) at last clinic visit were evaluated; GH persistence rates were based on diagnosis (IGHD or MPHD) and discontinuation category. Results: Patients who had achieved final height were on GH longer (46 ± 21 months, n = 288) than those who discontinued due to patient/caregiver decision (35 ± 15 months, n = 134), insurance issues (32 ± 21 months, n = 231), and other reasons (31 ± 18 months, n = 173). HSDS and corrected HSDS increased from baseline to year 3 across all categories (P lt;.0001). At year 3, patients in the final-height-achieved category had greater corrected HSDS (-0.3 ± 0.90, n = 179) than those who discontinued because of insurance issues (-0.6 ± 0.81, n = 63; P =.027) and other reasons (-1.0 ± 1.03, n = 55; P =.0006), and had the highest percentage of individuals reaching an HSDS of -2 or greater (96.4%, n = 190). Individuals in the final-height-achieved category were most persistent with GH therapy (P lt;.001). Conclusions: Patients who discontinued GH due to final height achieved had the highest persistence. Consistent insurance standards for GH therapy could improve persistence.

Original languageEnglish (US)
JournalAmerican Journal of Pharmacy Benefits
Volume6
Issue number1
StatePublished - Jan 1 2014

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