Persistent organic pollutants and promoter hypermethylation of the O-methylguanine-DNA methyltransferase gene

Soo Yeun Park, Ki Su Kim, Yu Mi Lee, Mi Jin Kim, David R. Jacobs, Miquel Porta, Dong Sun Kim, Duk Hee Lee

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Promoter hypermethylation of the O-methylguanine-DNA methyltransferase (MGMT) DNA repair gene is important during carcinogenesis. We explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), were associated with hypermethylation of the MGMT gene promoter in peripheral leukocytes among 368 Koreans without cancer. Hypermethylation decreased as OCPs increased (Ptrend=0.02), while PCB concentrations showed an inverted U-shaped association (Pquadratic<0.01). The prevalence of MGMT promoter hypermethylation was highest within the 2nd quintile of the PCB summary score (28.4%), while it was only 2.7% in the upper 10% score. Chronic exposure to these chemicals may affect methylation of the MGMT promoter, with possibly non-monotonic dose response relationships.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalBiomarkers
Volume20
Issue number2
DOIs
StatePublished - Mar 1 2015

Bibliographical note

Funding Information:
This work was partly supported by grants from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI13C0715) and the National Research Foundation of Korea (No. 2013R1A2A2A01068254).

Publisher Copyright:
© 2015 Informa UK Ltd. All rights reserved.

Keywords

  • MGMT
  • Methylation
  • Organochlorine pesticides
  • Persistent organic pollutants
  • Polychlorinated biphenyls

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