Personalized circadian timing of exercise

That exercise effects are circadian stage- dependent and that exercise at the wrong circadian stages can induce a Vascular Variability Disorder (VVD) has been documented earlier. Herein we show how statistically significant results can be obtained with a simple individualized design, that can be self-applied by everybody to optimize a desired effect by Chronobiologically-interpreted Ambulatory Blood Pressure (BP) and heart rate (HR) Monitoring C-ABPM). A 68-year old internist cardiologist monitored himself at half-hourly intervals, with interruptions, for 3- to7-day sessions, exercise timing being kept the same within a given session and changed from one session to another. Exercise training in the morning was associated with lowest BP and HR MESORs (Midline Estimating Statistic Of Rhythm, a rhythm-adjusted mean) as compared to exercise done at mid-day, late afternoon or in the evening. We review some of the literature, speculate about its meaning, yet do not stray beyond a single case in our conclusions for everybody: it seems possible and desirable to personalize exercise at a time of pertinence rather than convenience. One shoe or one timing does not fit all.