This review looks back on how the terpenoid indole alkaloid pathway and the regulatory factors in Catharanthus roseus were identified and characterized, and how metabolic engineering, including genetic engineering and metabolic profiling, was conducted based on the gained knowledge. In addition, further examination of the terpenoid indole alkaloid pathway is proposed.
|Original language||English (US)|
|Title of host publication||Biotechnology of Hairy Root Systems|
|Number of pages||32|
|State||Published - 2013|
|Name||Advances in Biochemical Engineering/Biotechnology|
Bibliographical noteFunding Information:
We thank Al Fu for helping to draw the regulation map of the TIA biosynthesis pathway, Fig. . This material is based upon work supported by the National Science Foundation under Award No. CBET-1066879. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.
- Catharanthus roseus
- Genetic engineering
- Metabolic engineering
- Metabolic profiling
- Terpenoid indole alkaloids