Perspectives of the Metabolic Engineering of Terpenoid Indole Alkaloids in Catharanthus roseus Hairy Roots

Le Zhao, Guy W. Sander, Jacqueline V. Shanks

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Scopus citations

Abstract

This review looks back on how the terpenoid indole alkaloid pathway and the regulatory factors in Catharanthus roseus were identified and characterized, and how metabolic engineering, including genetic engineering and metabolic profiling, was conducted based on the gained knowledge. In addition, further examination of the terpenoid indole alkaloid pathway is proposed.

Original languageEnglish (US)
Title of host publicationBiotechnology of Hairy Root Systems
EditorsPauline Doran
Pages23-54
Number of pages32
DOIs
StatePublished - 2013

Publication series

NameAdvances in Biochemical Engineering/Biotechnology
Volume134
ISSN (Print)0724-6145

Bibliographical note

Funding Information:
We thank Al Fu for helping to draw the regulation map of the TIA biosynthesis pathway, Fig. . This material is based upon work supported by the National Science Foundation under Award No. CBET-1066879. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

Keywords

  • Catharanthus roseus
  • Genetic engineering
  • Metabolic engineering
  • Metabolic profiling
  • Terpenoid indole alkaloids

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