TY - JOUR
T1 - PFK-2/FBPase-2
T2 - Maker and breaker of the essential biofactor fructose-2,6-bisphosphate
AU - Okar, David A.
AU - Lange, Alex J
AU - Manzano, Ànna
AU - Navarro-Sabatè, Aurèa
AU - Riera, Llus
AU - Bartrons, Ramon
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Fructose-2,6-bisphosphate is responsible for mediating glucagon-stimulated gluconeogenesis in the liver. This discovery has led to the realization that this compound plays a significant role in directing carbohydrate fluxes in all eukaryotes. Biophysical studies of the enzyme that both synthesizes and degrades this biofactor have yielded insight into its molecular enzymology. Moreover, the metabolic role of fructose-2,6-bisphosphate has great potential in the treatment of diabetes.
AB - Fructose-2,6-bisphosphate is responsible for mediating glucagon-stimulated gluconeogenesis in the liver. This discovery has led to the realization that this compound plays a significant role in directing carbohydrate fluxes in all eukaryotes. Biophysical studies of the enzyme that both synthesizes and degrades this biofactor have yielded insight into its molecular enzymology. Moreover, the metabolic role of fructose-2,6-bisphosphate has great potential in the treatment of diabetes.
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U2 - 10.1016/S0968-0004(00)01699-6
DO - 10.1016/S0968-0004(00)01699-6
M3 - Review article
C2 - 11165514
AN - SCOPUS:0035146957
SN - 0968-0004
VL - 26
SP - 30
EP - 35
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 1
ER -