Pharmacogenomics of autism spectrum disorder

Jacob T. Brown, Seenae Eum, Edwin H. Cook, Jeffrey R. Bishop

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and interactions as well as restricted, repetitive behaviors and interests. Pharmacologic interventions are often needed to manage irritability, aggressive behaviors and hyperactivity. Pharmacogenomic studies have investigated genetic associations with treatment response and side effects in an attempt to better understand drug mechanisms in hopes of optimizing the balance of symptom improvement versus side effects. The majority of pharmacogenomic studies to date have focused on antipsychotics, antidepressants and stimulants that are the most commonly utilized medication classes for ASD. This review is a comprehensive examination of the existing pharmacogenomic studies in ASD highlighting the current state of knowledge regarding genetic variation influencing pharmacokinetics and pharmacodynamics, and associated clinical outcomes.

Original languageEnglish (US)
Pages (from-to)403-414
Number of pages12
JournalPharmacogenomics
Volume18
Issue number4
DOIs
StatePublished - Mar 2017

Keywords

  • autism spectrum disorder
  • escitalopram
  • fluvoxamine
  • methylphenidate
  • pharmacogenetics
  • pharmacogenomics
  • risperidone

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