Pharmacokinetics of propylene glycol in humans during multiple dosing regimens

Dale K. Yu, William F. Elmquist, Ronald J. Sawchuk

Research output: Contribution to journalArticlepeer-review

Abstract

The pharmacokinetics of propylene glycol has been examined during multiple oral‐dosing regimens. The glycol is rapidly absorbed, with Cpmax observed within 1 h following administration. The terminal elimination half‐life is ∼4 h. After a minimum of 10 half‐lives of maintenance dosing on a fixed regimen, the accumulation of propylene glycol differed significantly among individuals because of variability in apparent clearance. The average apparent total body clearance is ∼0.1 L/kg · h and may be concentration dependent. The apparent volume of distribution is ∼0.5 L/kg, approximating total body water.

Original languageEnglish (US)
Pages (from-to)876-879
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume74
Issue number8
DOIs
StatePublished - Aug 1985

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