Pharmacologic features of proton pump inhibitors and their potential relevance to clinical practice

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9 Scopus citations

Abstract

In conclusion, PPIs differ slightly in their PK and PD properties and in their propensity to interact with other medications. Inhibition of acid secretion is a function of proton pump inhibition, and PPIs work in a similar fashion to achieve this goal. PK/PD principles can be used to optimize PPI therapy when considering issues related to administration, such as timing of drug delivery relative to the number of active pumps and the drug's AUC.

Original languageEnglish (US)
Pages (from-to)S25-S35
JournalGastroenterology Clinics of North America
Volume32
Issue number3 SUPPL.
DOIs
StatePublished - Sep 2003

Bibliographical note

Funding Information:
This work was supported by Wyeth Pharmaceuticals, Philadelphia, Pennsylvania.

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