Pharmacologic features of proton pump inhibitors and their potential relevance to clinical practice

Lynda S. Welage

doi:10.1016/S0889-8553(03)00056-6

Pharmacologic features of proton pump inhibitors and their potential relevance to clinical practice

Lynda S. Welage

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11 Scopus citations

Abstract

In conclusion, PPIs differ slightly in their PK and PD properties and in their propensity to interact with other medications. Inhibition of acid secretion is a function of proton pump inhibition, and PPIs work in a similar fashion to achieve this goal. PK/PD principles can be used to optimize PPI therapy when considering issues related to administration, such as timing of drug delivery relative to the number of active pumps and the drug's AUC.

Original language	English (US)
Pages (from-to)	S25-S35
Journal	Gastroenterology Clinics of North America
Volume	32
Issue number	3 SUPPL.
DOIs	https://doi.org/10.1016/S0889-8553(03)00056-6
State	Published - Sep 2003

Bibliographical note

Funding Information:
This work was supported by Wyeth Pharmaceuticals, Philadelphia, Pennsylvania.

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title = "Pharmacologic features of proton pump inhibitors and their potential relevance to clinical practice",

abstract = "In conclusion, PPIs differ slightly in their PK and PD properties and in their propensity to interact with other medications. Inhibition of acid secretion is a function of proton pump inhibition, and PPIs work in a similar fashion to achieve this goal. PK/PD principles can be used to optimize PPI therapy when considering issues related to administration, such as timing of drug delivery relative to the number of active pumps and the drug's AUC.",

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AB - In conclusion, PPIs differ slightly in their PK and PD properties and in their propensity to interact with other medications. Inhibition of acid secretion is a function of proton pump inhibition, and PPIs work in a similar fashion to achieve this goal. PK/PD principles can be used to optimize PPI therapy when considering issues related to administration, such as timing of drug delivery relative to the number of active pumps and the drug's AUC.

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Pharmacologic features of proton pump inhibitors and their potential relevance to clinical practice

Abstract

Bibliographical note

UN SDGs

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