Pharmacologic modulation of acute uveitis with aminonicotinamide

George E. Marak; Theodore W. Sery; Dale Gregerson; Larry A. Donoso; Narsing A. Rao

doi:10.1159/000267009

Pharmacologic modulation of acute uveitis with aminonicotinamide

George E. Marak, Theodore W. Sery, Dale Gregerson, Larry A. Donoso, Narsing A. Rao

Ophthalmology & Visual Neurosciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The hexose monophosphate shunt inhibitor 6-aminonicotinamide was observed to have an anti-inflammatory effect in the treatment of experimental uveitis. The electrons required for the reduction of molecular oxygen to superoxide radicals are generated by the pentose phosphate pathway in acute inflammatory cells. The inhibition of superoxide production is discussed as one of the potential antiphlogistic mechanisms.

Original language	English (US)
Pages (from-to)	111-116
Number of pages	6
Journal	Ophthalmic Research
Volume	22
Issue number	2
DOIs	https://doi.org/10.1159/000267009
State	Published - 1990

Keywords

6-Aminonicotinamide
Experimental uveitis
Hexose monophosphate shunt
Signal transduction
Superoxide anion
Toxic oxygen metabolites

Access

10.1159/000267009

OpenUrl availability

Full text

Cite this

@article{32fe3c50205a4c95a27c26c4b00bf98d,

title = "Pharmacologic modulation of acute uveitis with aminonicotinamide",

abstract = "The hexose monophosphate shunt inhibitor 6-aminonicotinamide was observed to have an anti-inflammatory effect in the treatment of experimental uveitis. The electrons required for the reduction of molecular oxygen to superoxide radicals are generated by the pentose phosphate pathway in acute inflammatory cells. The inhibition of superoxide production is discussed as one of the potential antiphlogistic mechanisms.",

keywords = "6-Aminonicotinamide, Experimental uveitis, Hexose monophosphate shunt, Signal transduction, Superoxide anion, Toxic oxygen metabolites",

author = "Marak, {George E.} and Sery, {Theodore W.} and Dale Gregerson and Donoso, {Larry A.} and Rao, {Narsing A.}",

year = "1990",

doi = "10.1159/000267009",

language = "English (US)",

volume = "22",

pages = "111--116",

journal = "Ophthalmic Research",

issn = "0030-3747",

publisher = "S. Karger AG",

number = "2",

}

TY - JOUR

T1 - Pharmacologic modulation of acute uveitis with aminonicotinamide

AU - Marak, George E.

AU - Sery, Theodore W.

AU - Gregerson, Dale

AU - Donoso, Larry A.

AU - Rao, Narsing A.

PY - 1990

Y1 - 1990

N2 - The hexose monophosphate shunt inhibitor 6-aminonicotinamide was observed to have an anti-inflammatory effect in the treatment of experimental uveitis. The electrons required for the reduction of molecular oxygen to superoxide radicals are generated by the pentose phosphate pathway in acute inflammatory cells. The inhibition of superoxide production is discussed as one of the potential antiphlogistic mechanisms.

AB - The hexose monophosphate shunt inhibitor 6-aminonicotinamide was observed to have an anti-inflammatory effect in the treatment of experimental uveitis. The electrons required for the reduction of molecular oxygen to superoxide radicals are generated by the pentose phosphate pathway in acute inflammatory cells. The inhibition of superoxide production is discussed as one of the potential antiphlogistic mechanisms.

KW - 6-Aminonicotinamide

KW - Experimental uveitis

KW - Hexose monophosphate shunt

KW - Signal transduction

KW - Superoxide anion

KW - Toxic oxygen metabolites

UR - http://www.scopus.com/inward/record.url?scp=0025232490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025232490&partnerID=8YFLogxK

U2 - 10.1159/000267009

DO - 10.1159/000267009

M3 - Article

C2 - 2140443

AN - SCOPUS:0025232490

SN - 0030-3747

VL - 22

SP - 111

EP - 116

JO - Ophthalmic Research

JF - Ophthalmic Research

IS - 2

ER -

Pharmacologic modulation of acute uveitis with aminonicotinamide

Abstract

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this