Phase-modulated rotating-frame spectroscopic localization using an adiabatic plane-rotation pulse and a single surface coil

Kristy Hendrich, Hellmut Merkle, Sally Weisdorf, William Vine, Michael Garwood, Kamil Ugurbil

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Spectroscopic spatial localization based on B1 gradients is generally performed as an amplitude-modulated experiment using a single surface coil, with a consequent loss in signal-to-noise ( S N) ratio. The phase-modulated implementation of such experiments with a single surface coil requires the ability to apply both B1-dependent rotations and B1-independent 90° plane rotations using the same surface coil. It is demonstrated that this is now possible using adiabatic plane-rotation pulses. These pulses can execute a plane rotation of any angle despite the presence of large B1 inhomogeneities; therefore, they can be used to perform a 90° plane rotation throughout the sensitive volume of a surface coil. A new phase-modulated, spatial-localization experiment based on B0 and B1 gradients (RAPP-ISIS) is introduced. It is shown, using phantom and in vivo, intact animal studies, that the technique provides excellent spectroscopic localization and the expected gain in S N compared to its amplitude-modulated analogue.

Original languageEnglish (US)
Pages (from-to)258-275
Number of pages18
JournalJournal of Magnetic Resonance (1969)
Volume92
Issue number2
DOIs
StatePublished - Apr 1991

Bibliographical note

Funding Information:
* This work was supported by NIH Grants HL33600, HL32247, AM 34931, CA50703 and the Vikings Children’s Fund. # Present address: Department of Pathology, University of Cincinnati, Cincinatti, Ohio 45267-07 14. * * To whom correspondence should be addressed at the Center for Magnetic Resonance Research.

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