Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet

Robert L Sorenson, Cathrine A. Sasek, Robert P. Elde

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


FMRF-NH2-like immunoreactivity was localized in the pancreatic polypeptide containing cells of the rat islet. FMRF-NH2 was investigated with regard to its effect on insulin, somatostatin and glucagon secretion from the isolated perfused rat pancreas. FMRF-NH2 (1 μM) significantly inhibited glucose stimulated (300 mg/dl) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. FMRF-NH2 (1 and 10 μM) was without effect on glucagon secretion, either in low glucose (50 mg/dl), high glucose (300 mg/dl), or during arginine stimulation (5 mM). These findings indicate that these FMRF-NH2 antisera recognize a substance in the pancreatic polypeptide cells of the islet which may be capable of modulating islet β and D cell activity.

Original languageEnglish (US)
Pages (from-to)777-782
Number of pages6
Issue number4
StatePublished - 1984

Bibliographical note

Funding Information:
The excellent technical assistance of Lynette Grouse, Marlys Rice and Jean Floyd is greatefully acknowledged. This research was supported by American Diabetes Association Minnesota Affiliate, lmmunonuclear Corporation and DA02148.


  • Insulin
  • Islet
  • Somatostatin


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