Abstract
A protecting group Ph(O) for terminal ethyne was newly developed. This protecting group can be introduced readily to terminal ethyne by CuI-catalyzed phosphination and subsequent oxidation with H Ph(O)-protected ethynes remained intact in Sonogashira coupling, and their high polarity enabled easy separation of the desired coupling product from by-products. By treatment with t-BuOK, Ph(O)-protected ethynes were transformed to the corresponding terminal ethynes.
Original language | English (US) |
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Article number | U04611ST |
Pages (from-to) | 2402-2406 |
Number of pages | 5 |
Journal | Synlett |
Issue number | 16 |
DOIs | |
State | Published - 2011 |
Keywords
- alkynes
- coupling
- phosphorylation
- protecting groups