Phosphonate analogs of carbocyclic phosphoribosylamine and carbocyclic glycinamide ribonucleotide

Robert Vince, Mei Hua, Carol A. Caperelli

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Analogs of intermediates in the de novo purine nucleotide biosynthetic pathway were synthesized to study the binding requirements of the corresponding enzymes. Because of the instability of the natural substrates, such as phosphoribosylamine, the use of the structurally stable phosphonate moiety and the carbocyclic ribose yields ideal analogs for these studies. In addition, these analogs can act as potential inhibitors of the de novo pathway leading to the design of anticancer agents. Enzyme studies with GAR synthetase and GAR transformylase reveal that the title compounds can act as substrates or inhibitors of the de novo enzymes.

Original languageEnglish (US)
Pages (from-to)1711-1718
Number of pages8
JournalNucleosides and Nucleotides
Volume15
Issue number11-12
DOIs
StatePublished - 1996

Bibliographical note

Funding Information:
Acknowledgments. This work was supported by National Institutes of Health Grants KO1 CA23263 (R.V.), R01 GM46243 (C.A.C.), and KO1 GM42663 (C.A.C.)

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