Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair

Zhimin Peng, Zhongping Liao, Barbara Dziegielewska, Yoshi Matsumoto, Stefani Thomas, Yunhu Wan, Austin Yang, Alan E. Tomkinson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Phosphorylation of human DNA ligase I (hLigI) regulates its participation in DNA replication and repair. Results: Identification of a single phosphorylation site that regulates the interaction of hLigI with replication factor C (RFC). Conclusion: Interaction between hLigI and RFC is critical for DNA replication and repair. Significance: We provide insights into the mechanism by which a single phosphorylation site regulates the cellular functions of hLigI.

Original languageEnglish (US)
Pages (from-to)36711-36719
Number of pages9
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012
Externally publishedYes

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